This study examines the activity of hippocampal CA, pyramidal neurons during conditioned fear stress (CFS)-induced freezing behavior in unanesthetized, unrestrained rats. The firing frequency of hippocampal CA1 pyramidal neurons was significantly decreased when conditioned rats exhibited freezing behavior. Firing frequency returned to the baseline after freezing behavior disappeared. The selective 5-hydroxytryptamine (5-HT)1A antagonists, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide (WAY-100635), and N-tert-butyl-3-[4-(2-methoxyphenyl)piperazine-1-yl]-2-phenylpropamide (WAY-100135) and 5-HT depletion with parachlorophenylalanine (PCPA) completely abolished the decrease in firing frequency during CFS-induced freezing behavior. These results suggested that endogenous 5-HT inhibited the firing activity of hippocampal CA1 pyramidal neurons during CFS-induced freezing behavior mainly through stimulating 5-HT1A receptors.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/hipo.10178 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Reexamining the Enhanced Solubility of Sodium Laurate/Sodium Oleate Eutectic Mixtures.
Langmuir
January 2025
Unilever R&D, 40 Merrit Boulevard, Trumbull, Connecticut 06611, United States.
Mixtures of multiple surfactants that have superior performance to the individual components are highly sought-after commercially. Mixtures with a reduced Krafft point () are particularly useful as they enable applications at lower temperatures. Such an example is the soap maker's eutectic: the mixture of sodium laurate (NaL) and sodium oleate (NaOl).
View Article and Find Full Text PDFParabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat.
Elife
January 2025
School of Psychology, Korea University, Seoul, Republic of Korea.
Recent studies suggest that calcitonin gene-related peptide (CGRP) neurons in the parabrachial nucleus (PBN) represent aversive information and signal a general alarm to the forebrain. If CGRP neurons serve as a true general alarm, their activation would modulate both passive nad active defensive behaviors depending on the magnitude and context of the threat. However, most prior research has focused on the role of CGRP neurons in passive freezing responses, with limited exploration of their involvement in active defensive behaviors.
View Article and Find Full Text PDFGenome-wide identification of CAMTA gene family in teak (Tectona grandis) and functional characterization of TgCAMTA1 and TgCAMTA3 in cold tolerance.
BMC Plant Biol
January 2025
Research Institute of Tropical Forestry, Chinese Academy of Forestry, Guangzhou, 520521, China.
Background: Calmodulin-binding transcription activator (CAMTA) proteins play significant roles in signal transduction, growth and development, as well as abiotic stress responses, in plants. Understanding their involvement in the low-temperature stress response of teak is vital for revealing cold resistance mechanisms.
Results: Through bioinformatics analysis, the CAMTA gene family in teak was examined, and six CAMTA genes were identified in teak.
Activity of a descending neuron associated with visually elicited flight saccades in Drosophila.
Curr Biol
January 2025
Research Group Neurobiology of Flight Control, Max Planck Institute for Neurobiology of Behavior - caesar, 53175 Bonn, Germany. Electronic address:
Approaching threats are perceived through visual looming, a rapid expansion of an image on the retina. Visual looming triggers defensive responses such as freezing, flight, turning, or take-off in a wide variety of organisms, from mice to fish to insects. In response to looming, flies perform rapid evasive turns known as saccades.
View Article and Find Full Text PDFEffect of freeze-thaw processes on the water-absorption ability and mechanical properties of hydrogel pads with chitosan/poly(vinyl alcohol) based on citrate crosslinks.
Food Chem
January 2025
College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China. Electronic address:
In this study, the effect of freeze-thaw (F-T) processes on the mechanical and water absorption performance of citrate cross-linked chitosan/poly(vinyl alcohol) hydrogel pads was evaluated. An excellent cross-linking of 4 % (w/w) citrate was indicated by enhanced peak strength in Fourier-transform infrared spectroscopy and X-ray diffraction patterns, which was applied to the subsequent F-T process. The results in the deswelling rate, water contact angle, and relaxation time of samples exhibited a tendency to decrease and then increase with increasing F-T cycles, reaching a minimum of 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!