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20-Hydroxyeicosatetraenoic Acid Regulates the Src/EGFR/NF-κB Signaling Pathway Via GPR75 to Activate Microglia and Promote TBI in the Immature Brain.
Neurochem Res
November 2024
Department of Anesthesiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
20-Hydroxyeicosatetraenoic acid (20-HETE) is associated with secondary damage in traumatic brain injury (TBI) of the immature brain. Microglial activation is pivotal in this process. However, the underlying mechanism of action remains unknown.
View Article and Find Full Text PDFIntroduction of a carboxylic acid group into pyrazolylpyridine derivatives increased selectivity for inhibition of the 20-HETE synthase CYP4A11/4F2.
Bioorg Med Chem
October 2023
Taisho Pharmaceutical Co., Ltd, 1-403, Yoshino-Cho, Kita-Ku, Saitama, Saitama 331-9530, Japan. Electronic address:
20-Hydroxyeicosatetraenoic acid (20-HETE) is a lipid mediator and one of the major arachidonic acid metabolites whose formation is mainly catalyzed by the enzymes cytochrome P450 (CYP) 4F2 and CYP4A11. Several studies have suggested that 20-HETE is involved in the pathogenesis of renal diseases, including diabetic nephropathy and autosomal dominant polycystic kidney disease, and we previously reported compound 1 as a dual inhibitor of CYP4A11/4F2 with therapeutic potential against renal fibrosis. Subsequent studies revealed that compound 1, the dual CYP4A11/4F2 inhibitor, however, exhibited low selectivity over another CYP4F subtype, CYP4F22, which catalyzes ω-hydroxylation of ultra-long-chain fatty acids (ULCFAs); ULCFAs are important for the formation of acylceramides, which play a role in skin barrier formation.
View Article and Find Full Text PDFSalidroside attenuates sepsis-induced acute lung injury by inhibiting ferroptosis-dependent pathway.
Korean J Physiol Pharmacol
November 2024
The Second Clinical Medical School, Lanzhou University, Lanzhou 730030, Gansu, China.
Article Synopsis
- Sepsis can lead to acute lung injury (ALI) due to a strong inflammatory response, and salidroside (SAL) is known for its anti-inflammatory and antioxidant effects.
- The study investigated how SAL affects ALI in a septic mouse model, analyzing lung tissue damage, inflammatory factors, and the ferroptosis pathway.
- Results showed that SAL treatment improved lung tissue health, reduced harmful inflammatory markers, and inhibited ferroptosis, indicating its potential as a therapeutic option for sepsis-induced ALI.
20-HETE, Blood Pressure, and Vascular Stiffness in Young Adults.
Hypertension
December 2024
Medical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Australia (A.E.B., S.S., L.J.B., T.A.M.).
Article Synopsis
- This study explored the role of cytochrome-P450 eicosanoids, specifically 20-HETE and EETs, in regulating blood pressure and vascular stiffness among 1,054 young adults.
- Researchers found that higher plasma levels of 20-HETE were positively associated with increased systolic blood pressure and vascular stiffness measurements, even after accounting for other factors like sex and body mass index.
- The study concluded that 20-HETE significantly influences blood pressure and vascular health in young adults, while EETs did not show a significant impact in these areas.
Unraveling cadmium-driven liver inflammation with a focus on arachidonic acid metabolites and TLR4/ IκBα /NF-κB pathway.
Ecotoxicol Environ Saf
November 2024
School of Life Sciences, Jiangsu University, Zhenjiang 212000, China. Electronic address:
Epidemiological studies have demonstrated exposure to cadmium ion (Cd) is significantly associated with the incidence and aggravation of nonalcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH). Cd exposure could alter lipid metabolism, and changed lipid metabolites are significantly associated with NASH. Arachidonic acid (ArA) is an omega-6 polyunsaturated fatty acid.
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