The aim of the study was to evaluate the frequency of depression in patients with Parkinson's disease. The authors recruited 85 patients with idiopathic Parkinson's disease, 42 males and 43 females aged 34-82 years (mean age 68.7). Age at onset ranged 24-79 (mean 60.9 years). Disease duration ranged from 3 month to 20 years (mean 7.86 years). In 62 patients (72.94%) mixed type of the disease was diagnosed, in 14 (16.47%) tremor and in 9 (10.59%) rigidity predominated. UPDRS was used to evaluate the severity of the disease (results ranged 28-90, mean 51.4). Activity of daily living was estimated according to Schwab and England Scale (range 40-90, mean 68.1). Depression was evaluated with Hamilton, Beck and Montgomery-Asberg scales. The results were analysed with Spearman correlation. Depression was diagnosed in 53 (62.35%) patients [in 7 (8.24%) light; in 14 (16.47%) middle; in 19 (22.35%) heavy; in 13 (15.29%) very heavy]. The results acquired with all three scales were not statistically different. There were significant positive correlations between depression and female sex, severity of the disease, dyskinesia as side effect of.
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Neurosurg Rev
January 2025
School of Medicine, The University of Jordan, Amman, 11942, Jordan.
Deep brain stimulation (DBS) effectively treats Parkinson's disease (PD) motor symptoms, highlighting a gap in understanding current research trends and future directions. This study aims to analyze DBS literature systematically using bibliometric methods to map trends and identify opportunities. A total of 6,041 publications on DBS for PD from 1993 to 2023 were retrieved from the Web of Science Core Collection (WoSCC) on July 24, 2023.
View Article and Find Full Text PDFNPJ Parkinsons Dis
January 2025
Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
This study explores the effect of risk factors on the progression of idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) to α-synucleinopathies in a Chinese cohort. Patients with iRBD were enrolled and assessed for environmental factors and lifestyle using standardized structured questionnaires at baseline. All patients were prospectively followed for phenoconversion monitoring.
View Article and Find Full Text PDFWorld Neurosurg
January 2025
Department of Neurosurgery, Hopital Bretonneau, Tours, France. Electronic address:
Purpose: Lumbar disc herniation, canal stenosis and cervicarthrosis are degenerative spinal pathologies frequently observed in the aging population of patients with Parkinson Disease (PD). Spinal surgery in PD patients remains risky with uncertain functional results. The main issue is to determine whether a surgical procedure should be performed on PD patients with common degenerative spinal pathologies (CDSP).
View Article and Find Full Text PDFProg Biomed Eng (Bristol)
January 2025
Tehran University of Medical Sciences, Hassan-Abad Square, Imam-Khomeini Ave., Tehran, 11365-3876, Tehran, 1416753955, Iran (the Islamic Republic of).
Traumatic brain injuries (TBIs) pose a significant health concern among the elderly population, influenced by age-related physiological changes and the prevalence of neurodegenerative diseases. Understanding the biomechanical dimensions of TBIs in this demographic is vital for developing effective preventive strategies and optimizing clinical management. This comprehensive review explores the intricate biomechanics of TBIs in the elderly, integrating medical and aging studies, experimental biomechanics of head tissues, and numerical simulations.
View Article and Find Full Text PDFBiochemistry
January 2025
Sunita Sanghi Centre of Aging and Neurodegenerative Diseases (SCAN), Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
Aggregation of α-synuclein (α-Syn) and Lewy body (LB) formation are the key pathological events implicated in Parkinson's disease (PD) that spread in a prion-like manner. However, biophysical and structural characteristics of toxic α-Syn species and molecular events that drive early events in the propagation of α-Syn amyloids in a prion-like manner remain elusive. We used a neuronal cell model to demonstrate the size-dependent native biological activities of α-Syn fibril seeds.
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