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A rare well-differentiated renal retroperitoneal liposarcoma: a case report.
Ann Med Surg (Lond)
October 2024
Department of Urology, Aleppo University Hospital, Aleppo, Syria.
Article Synopsis
- Retroperitoneal liposarcomas (RPLPSs) are uncommon tumors arising from mesenchymal cells in the peritoneal cavity, with renal cases being especially rare; only 45 instances have been documented.* -
- A case study of a 44-year-old woman revealed that she had RPLPS, identified due to symptoms like hirsutism and an abdominal mass, which was confirmed via imaging and needle biopsy; she successfully underwent surgery.* -
- RPLPSs are primarily asymptomatic until they grow large, categorized into five subtypes, and while they seldom metastasize, they often recur; they can compress nearby structures like the adrenal gland.*
Safety and Efficacy of Percutaneous Cryoablation for Recurrent or Metastatic Soft-Tissue Sarcoma in Adult Patients.
AJR Am J Roentgenol
October 2024
Department of Interventional Radiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030-4009.
Article Synopsis
- Treatment options for recurrent or metastatic soft-tissue sarcoma (STS) are limited after initial therapies, which is where percutaneous cryoablation could serve as a minimally invasive alternative for local control.
- A study conducted on 141 patients showed that among 217 cryoablation procedures, the procedure had a low complication rate of 2% and achieved adequate coverage for 82% of tumors.
- The 1-year local progression-free survival rate was 86%, with overall survival rates of 89% at 1 year and 80% at 2 years, suggesting effective outcomes for patients with treatment-refractory STS.
Intraperitoneal Dedifferentiated Liposarcoma: Unveiling a Rare Diagnosis in Peritoneal Fluid Cytology - A Case Report with Literature Review.
Acta Cytol
November 2024
Division of Oncopathology, Department of Pathology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.
Introduction: Sarcomas presenting as malignant effusions are rare, and diagnosing them on fluid cytology requires expertise and clinicoradiological correlation as cells undergo morphological changes, mimicking carcinoma or mesothelioma.
Case Presentation: We present a case of a 70-year-old man with abdominal distention and pain, initially suggestive of carcinoma on peritoneal fluid cytology. However, subsequent analysis with immunohistochemistry on the cell block revealed diffuse nuclear positivity for MDM2, leading to the diagnosis of dedifferentiated liposarcoma.
PLAG1-Rearranged Uterine Sarcomas: A Study of 11 Cases Showing a Wide Phenotypical Spectrum Not Limited to Myxoid Leiomyosarcoma-Like Morphology.
Mod Pathol
September 2024
Bioptical Laboratory, Ltd, Pilsen, Czech Republic; Department of Pathology, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czech Republic.
Article Synopsis
- The PLAG1 gene fusions have been found in some uterine myxoid leiomyosarcomas (M-LMS), but there are cases of PLAG1-rearranged uterine sarcomas that do not resemble M-LMS or show smooth muscle markers.
- A study involving 11 cases of these sarcomas showed diverse features, with patient ages ranging from 34 to 72 years and tumor sizes between 6.5 to 32 cm.
- Follow-up data indicated varying outcomes; while some patients showed no disease evidence, others experienced disease progression or died within a few years, and the tumors displayed significant morphological diversity, including unusual characteristics like hyalinized stroma and adipocytic differentiation
Intraperitoneal Liposarcoma: A Case Report and Literature Review of a Rare Entity.
Cureus
April 2024
Radiology, King Fahad Medical City, Riyadh, SAU.
Liposarcoma is a rare soft-tissue neoplasm originating from adipocytes. The exact cause of liposarcoma is unknown and symptoms vary depending on the tumor's location. A 49-year-old man presented to the emergency room complaining of epigastric pain radiating to the back and right upper quadrant.
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