The authors relate the results of examining 120 patients with functional disorders of the colon. The majority of the patients manifested diverse mental abnormalities of the neurotic origin, represented by different patterns of mental pathology, somatized disturbances, neuroses and psychopathies. The conditions favouring the origin of neurotic and functional disorders have been elucidated. It is concluded from the comparison of different treatment modalities that psychotherapy may be preferred.
Download full-text PDF |
Source |
---|
Elife
March 2025
Department of Surgery, Weill Cornell Medicine, New York, United States.
Haploinsufficiency for is associated with congenital heart disease (CHD) with variable comorbidity of pancreatic or diaphragm defects, although the etiology of disease is not well understood. Here, we used cardiac directed differentiation from human embryonic stem cells (hESCs) as a platform to study GATA6 function during early cardiogenesis. GATA6 loss-of-function hESCs had a profound impairment in cardiac progenitor cell (CPC) specification and cardiomyocyte (CM) generation due to early defects during the mesendoderm and lateral mesoderm patterning stages.
View Article and Find Full Text PDFTransl Vis Sci Technol
March 2025
Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Purpose: We aimed to analyze retinal neurovascular unit (RNVU) alterations and function via optical coherence tomography angiography (OCTA) and full-field electroretinography (ERG) in patients with ischemic stroke (IS).
Methods: OCTA was used to measure RNVU changes in 229 participants (101 with IS and 128 healthy controls). The RETeval device was used to record full-field electroretinograms (FERGs) in 40 participants (14 with IS and 26 healthy controls).
J Contemp Dent Pract
December 2024
Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, India; Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania "Luigi Vanvitelli", Naples, Italy, Phone: +39 3289129558, e-mail:
Uzunçıbuk H, Fiorillo L, Ronsivalle V, . Unraveling the Complexities of Sleep Disturbances: A Scientific Perspective. J Contemp Dent Pract 2024;25(12):1081-1083.
View Article and Find Full Text PDFAnn Med
December 2025
Cancer Center, The First Hospital of Jilin University, Changchun, China.
Introduction: Since the Fourth edition of the WHO classification, PPGLs have been recognized for their metastatic potential, though no clear features can accurately predict this behavior. The prognostic value of Ki-67 in assessing the risk of progression, relapse, or metastasis in PPGLs remains debated.
Methods: This cohort study included 501 patients diagnosed with PPGLs at the First Hospital of Jilin University between 2000 and 2022, with clinical data, treatment details, pathological indicators, and germline gene test results collected.
Oncoimmunology
December 2025
Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.
We conducted a phase Ib/II clinical trial to evaluate the safety, feasibility, and clinical activity of combining pembrolizumab (anti-PD-1) with XL888 (Hsp90 inhibitor) in patients with advanced colorectal cancer (CRC). We hypothesized that this regimen would modulate soluble and cellular immune mediators and enhance clinical outcomes. The trial employed a 3 + 3 open-label design, with an expansion cohort at the recommended phase II dose (RP2D) in treatment-refractory, mismatch repair-proficient CRC patients.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.