AI Article Synopsis
- - The study examined the immune status of patients with chronic hepatitis (CH) caused by viral, alcoholic, and toxic factors, focusing on T-cell immunity using monoclonal antibodies and flow laser cytometry.
- - Findings indicated a general impairment in the immune system of CH patients, specifically a decrease in certain T-cell subpopulations (OKT-3+, OKT-4+, OKT-8+) and an imbalance between OKT-4+ and OKT-8+ cells, with variations depending on the hepatitis cause.
- - The results suggest that these immune changes reflect a secondary immunodeficiency in T-cells, which could be important for diagnosing CH and creating targeted immunotherapy treatments.
Article Abstract
A study was made of the immune status in patients suffering from chronic hepatitis (CH) of viral, alcoholic and toxic etiology. The T-system cellular immunity (OKT-3+, OKT-4+, OKT-8+, OKT-11+) was subjected to a subpopulation analysis using monoclonal antibodies and flow laser cytometry. CH of varying etiology is marked by impairment of the immune status. Especially manifest are suppression of OKT-3(+)-, OKT-4(+)-, OKT-8(+)-positive cells and imbalance of OKT-4+ and OKT-8+, with the changes revealed being dependent on the etiological pattern of CH. The data obtained point to the development of secondary immunodeficiency of the T-cell component at the level of different T lymphocyte subpopulations, which depends on the clinico-morphological and etiological pattern of CH. The revealed changes in the immune system may serve as a criterion for differential diagnosis and elaboration of efficient immunocorrective therapy of CH.
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