The carcinogenic amino-alpha-carbolines, 2-amino-9H-pyrido[2,3-b]indole and AalphaC, have been measured in airborne particles, rain water, soil and cigarette-smoke-polluted indoor air by high-performance liquid chromatography. These carcinogens were found in all kinds of environmental samples examined, although MeAalphaC was not detected in soil. Considering the present results, together with the previous findings that these carcinogens were present in foodstuffs, cigarette smoke and diesel-exhaust particles, amino-alpha-carbolines are likely to be ubiquitous environmental pollutants. Our data also support the hypothesis that amino-alpha-carbolines are formed through combustion of various materials such as food, grass and petroleum.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0269-7491(92)90130-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Two food-borne heterocyclic amines: metabolism and DNA adduct formation of amino-alpha-carbolines.
Mol Nutr Food Res
March 2005
Department of Toxicology and Risk Assessment, Danish Institute for Food and Veterinary Research, Søborg, Denmark.
The amino-alpha-carbolines 2-amino-9H-pyrido[2,3-b]indole (AalphaC) and 2-amino-3-methyl-9H-pyrido-[2,3-b]indole (MeAalphaC) are two mutagenic and carcinogenic heterocyclic amines formed during ordinary cooking. Amino-alpha-carbolines can be formed in model systems by pyrolyzing tryptophan or proteins of animal or vegetable origin, furthermore they are found in many cooked foods, such as fish, meat, and chicken. The specific mutagenicity of the amino-alpha-carbolines are lower in the Ames Salmonella assay than other heterocyclic amines, but in rodent studies the carcinogenicity of the amino-alpha-carbolines are comparable to other heterocyclic amines.
View Article and Find Full Text PDFThe food mutagen 2-amino-9H-pyrido[2,3-b]indole (AalphaC) but not its methylated form (MeAalphaC) increases intestinal tumorigenesis in neonatally exposed multiple intestinal neoplasia mice.
Carcinogenesis
August 2002
Department of Food Toxicology, Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404 Nydalen, N-0403, Oslo, Norway.
The heterocyclic amines 2-amino-9H-pyrido[2,3-b]indole (AalphaC) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC) are carcinogenic in several organs in rodents, but not in the intestinal tract. However, AalphaC induces DNA adducts, mutations and preneoplastic aberrant crypt foci (ACF) in rodent colons. The purpose of this study was to examine whether AalphaC and MeAalphaC could affect intestinal tumorigenesis in C57BL/6J-Min/+ (multiple intestinal neoplasia) mice.
View Article and Find Full Text PDFOccurrence of carcinogenic amino-alpha-carbolines in some environmental samples.
Environ Pollut
January 2005
Department of Hygiene and Preventive Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan.
The carcinogenic amino-alpha-carbolines, 2-amino-9H-pyrido[2,3-b]indole and AalphaC, have been measured in airborne particles, rain water, soil and cigarette-smoke-polluted indoor air by high-performance liquid chromatography. These carcinogens were found in all kinds of environmental samples examined, although MeAalphaC was not detected in soil. Considering the present results, together with the previous findings that these carcinogens were present in foodstuffs, cigarette smoke and diesel-exhaust particles, amino-alpha-carbolines are likely to be ubiquitous environmental pollutants.
View Article and Find Full Text PDF[Carcinogenic heterocyclic amines in the environment].
Nihon Eiseigaku Zasshi
October 1991
Department of Hygiene & Preventive Medicine, Faculty of Medicine, University of Tokyo.
The purpose of this report is to summarize data on carcinogenic heterocyclic amines mainly from the aspect of environmental medicine. Since 1977, a new series of heterocyclic amines has been isolated as potent mutagens and they have been shown to be carcinogenic to experimental animals. Among these carcinogens, carcinogenic amino-alpha-carbolines and amino-gamma-carbolines are widely distributed in such components of the environment as airborne particles, rain water, cigarette smoke, diesel exhaust particles and cooked foods.
View Article and Find Full Text PDFDetection of carcinogenic amino-alpha-carbolines and amino-gamma-carbolines in diesel-exhaust particles.
Environ Pollut
May 2004
Department of Hygiene & Preventive Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan.
Diesel-exhaust particles are known to contain mutagenic and carcinogenic chemicals. The aim of this study was to determine whether carcinogenic amino-alpha-carbolines and amino-gamma-carbolines are present in diesel-exhaust particles. These carcinogens which were originally isolated from pyrolysates of proteins and amino acids have been detected in diesel-exhaust particles obtained from two test vehicles as well as in standard materials of automobile-exhaust particles obtained from National Institute for Environmental studies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!