[Immune response in non-inbred rats after implantation of Geren carcinoma into their spleens].

Formation of specific immune response of Geren's carcinoma (GC) versus its biological properties was studied in non-inbred rat spleen. GC growth was accompanied by mounting immune response to tumor-associated antigens (TAA) which was evaluated by macrophage adherence inhibition test. Increase in cell-mediated response to such antigens passed through stages determined by the peculiarities of GC growth in spleen tissues. Immune response to TAA was reported in half the animals as the cells were taking. Enhanced proliferative pool of tumor, aneuploidy and DNA index offset by the low level of apoptosis were characteristic of tumor progression stage. The combination of those factors served as a backdrop for immunologic tolerance development in all the animals. Immune response resurfaced as apoptosis intensified during generalized tumor growth when cell proliferation in the parenchyme declined.