This study examined the effect of low- and high-pulse frequency stimulus electroconvulsive therapy on seizure physiology and therapeutic outcome. Forty depressed patients randomly received either low (n = 19) or high (n = 21) pulse frequency stimulus during a course of right unilateral electroconvulsive therapy. The current and pulse width were kept constant whereas the duration was proportionately varied. The two groups were compared for seizure parameters and therapeutic outcome. Low frequency stimulus group had lower threshold and less subconvulsive stimulation. There were no differences in seizure durations, ictal cardiovascular responses and therapeutic outcome between the two groups. Low frequency stimulus produced seizure at lower stimulus dose without affecting seizure parameters and therapeutic effects.
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