Objective: To determine the effectiveness of analgesia, with or without sciatic nerve blockade, after open repair of calcaneus fracture.
Design: Randomized, prospective trial involving 30 patients divided into 3 groups of 10, all having open repair of calcaneus fractures. Group 1 used morphine patient-controlled analgesia alone. Groups 2 and 3 had morphine patient-controlled analgesia and a "one-shot" bupivacaine sciatic nerve blockade, either presurgically (group 2) or postsurgically (group 3).
Setting: Harborview Medical Center operating rooms and orthopedic floors.
Outcome Measures: Morphine use over 24 hours, visual analogue scale pain scores, and sciatic nerve blockade duration.
Results: In the absence of sciatic nerve blockade, initial postoperative pain was marked, even with a mean recovery room dose of intravenous morphine more than 30 mg. Sciatic nerve blockade with bupivacaine had a mean duration of 14 hours and substantially reduced pain for the first 24 postoperative hours. Presurgical blockade confers no advantage over postsurgical blockade.
Conclusion: Sciatic nerve blockade confers significant benefit over morphine alone for analgesia after open repair of calcaneus fractures. Postsurgical sciatic nerve blockade provides the longest possible postoperative block duration.
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http://dx.doi.org/10.1097/00005131-200404000-00001 | DOI Listing |
J Appl Biomater Funct Mater
March 2025
Kerman Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Peripheral nerve tissue engineering is a field that uses cells, growth factors and biological scaffold material to provide a nutritional and physical support in the repair of nerve injuries. The specific properties of injectable human amniotic membrane-derived hydrogel including growth factors as well as anti-inflammatory and neuroprotective agents make it an ideal tool for nerve tissue repair, and metformin may also aid in nerve regeneration. The aim of this study was to investigate the effects of hydrogel derived from amniotic membrane (AM) along with metformin (MET) administration in the repair of sciatic nerve injury in male rats.
View Article and Find Full Text PDFBackground: Osseointegration (OI) has revolutionized prosthetic rehabilitation for amputees. Despite its contributions, postamputation pain remains a significant problem. This study aims to investigate the role of sciatic nerve regenerative peripheral nerve interface (RPNI) in patients undergoing transfemoral OI, focusing on its impact on pain and prosthetic wear.
View Article and Find Full Text PDFCNS Neurol Disord Drug Targets
March 2025
University Institute of Chemical Technology, KBC North Maharashtra University, Jalgaon 425001, MS, India.
Introduction: The polyol pathway is responsible for the metabolism of almost one-third of the total glucose in people with chronic diabetes. Moreover, it causes complications in organs that rely on aldose reductase (AR) as an enzyme. The purpose of this research was to examine the in vitro and in vivo effects of a flavonoid-rich ethyl acetate fraction of a methanolic extract of Ficus carica Lam.
View Article and Find Full Text PDFDiabetes Metab J
March 2025
R&D, Dompé Farmaceutici SpA, L'Aquila, Italy.
Background: The CXC motif chemokine ligand 8 (CXCL8)-CXC motif chemokine receptor 1/2 (CXCR1/2) axis has been implicated in type 1 diabetes mellitus (T1DM). Its actions on non-immune cells may also contribute to T1DM-associated complications, including painful diabetic peripheral neuropathy (DPN) and diabetic retinopathy (DR).
Methods: We assessed the efficacy of early (4-8 weeks) or late (8-12 weeks) daily ladarixin (LDX) for the treatment of streptozotocin (STZ)-induced T1DM and the related complications of DPN or DR in male rats.
Photochem Photobiol
March 2025
Department of Laser Medicine, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Photobiomodulation (PBM) has demonstrated potential in promoting peripheral nerve regeneration. However, there is a limited and inconclusive study on the application of light-emitting diode (LED) for nerve injury repair. In this study, we designed an 807-nm LED device with high luminous uniformity to investigate the effects of LED-based PBM on peripheral nerve injury repair.
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