Study Design: A repeated-measures design using a cadaveric model was used in this preliminary investigation on the effectiveness of spine-board transfer techniques.
Objectives: To compare the amount of angulation (flexion-extension) motion that results at the cervical spine during the execution of the log-roll maneuver and the lift-and-slide technique; and to examine how changes to the integrity of the cervical spine impacts the amount of motion generated during the transfer process.
Summary Of Background Data: Very little research has been performed to establish the efficacy of spine-board transfer techniques. Early studies have indicated that the log-roll maneuver may not be appropriate for transferring victims with thoracolumbar injuries. Also, there has not been a single study that has reported the impact of transfer techniques on the unstable cervical spine. This lack of data necessitated the present study.
Methods: Four groups (with six participants each) were asked to execute the log-roll maneuver and the lift-and-slide technique on five cadavers. An electromagnetic motion analysis device was used to assess the amount of angulation motion generated at the C5-C6 segment during the execution of these transfer techniques. To examine how changes to the integrity of the cervical spine impacts the amount of motion that is produced during the transfer process, flexion-extension motion was assessed under various conditions: across a stable C5-C6 segment, after the creation of a posterior ligamentous injury, and after a complete segmental injury.
Results: No significant differences in angulation motion were noted between transfer techniques. However, significant differences were noted between all three injury conditions. That is, as the severity of the injury increased, the average amount of angulation motion produced at the site of the lesion also increased, regardless of technique.
Conclusion: The participants of this study were able to restrict flexion-extension motion equally well with thelog-roll maneuver as with the lift-and-slide technique. However, more research is needed to fully ascertain the effectiveness of spine-board transfer techniques.
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http://dx.doi.org/10.1097/01.brs.0000116986.48166.d0 | DOI Listing |
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Institut Sénégalais de Recherches Agricoles (ISRA/Centre d'Etude Regional pour l'Amélioration de l'Adaptation à la Sécheresse (CERAAS), Thies, Senegal.
Early leaf spot (ELS), caused by (syn. ), is a highly damaging peanut disease worldwide. While there are limited sources of resistance in cultivated peanut cultivars, wild relatives carry alleles for strong resistance, making them a valuable strategic resource for peanut improvement.
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Radboud University Medical Center, Nijmegen, The Netherlands.
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Departament de Farmàcia i Tecnologia Farmacèutica, i Fisicoquímica, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona (UB) Barcelona Spain
Förster resonance energy transfer (FRET) is a powerful technique used to investigate the conformational preferences of biosystems, and molecular simulations have emerged as an ideal complement to FRET due to their ability to provide structural models that can be compared with experiments. This synergy is however hampered by the approximations underlying Förster theory regarding the electronic coupling between the participating dyes: a dipole-dipole term attenuated by a simple dielectric screening factor 1/ that depends on the refractive index of the medium. Whereas the limits of the dipole approximation are well-known, detailed insights on how environment effects deviate from the 1/ assumption and modify the distance dependence that characterizes FRET as a spectroscopic ruler are still not well understood, especially in biosystems characterized by significant structural disorder.
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January 2025
Department of Chemistry, University of York York YO10 5DD UK
C-N atropisomeric amides are important compounds in medicinal chemistry and agrochemistry. Atropselective methods for their synthesis are therefore important. In this study, a novel strategy to make C-N atropisomeric amides based on intramolecular acyl transfer a tethered Lewis basic pyridine or tertiary amine group is reported.
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