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Patterns, determinants, and outcomes of early use of antidementia drugs: A 6-year multicenter cohort study in Thailand.
Arch Gerontol Geriatr
March 2025
Unit of Excellence on Research in Health Outcomes and Patient Safety in Elderly, School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand; Division of Social and Administrative Pharmacy (SAP), Department of Pharmaceutical Care, School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand. Electronic address:
Background: Evidence on antidementia drugs (ADD) use in developing countries, where accessibility to ADD is challenging, is limited. Our aim was to examine prescribing patterns, factors, and outcomes associated with the early-ADD use (within 3 months from diagnosis) in people with dementia.
Methods: A retrospective cohort study included individuals aged ≥ 60 years with dementia from three hospitals in Thailand between 2015 and 2020.
Multicenter Evaluation of Memory Remediation in Traumatic Brain Injury With Donepezil: A Randomized Controlled Trial.
J Neuropsychiatry Clin Neurosci
December 2024
Behavioral Neurology Section, Department of Neurology, University of Colorado School of Medicine, Aurora (Arciniegas); Brain Injury Research Center, TIRR Memorial Hermann, Houston (Arciniegas, Sander, Sherer); H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston (Arciniegas, Sander, Bogaards, Sherer); Research Department, Craig Hospital, Englewood, Colo. (Almeida, Harrison-Felix, Ketchum, Mellick); Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, Mass. (Giacino, Zafonte); Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston (Giacino, Zafonte); Rehabilitation Hospital of Indiana, Indianapolis (Hammond); Department of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis (Hammond); Moss Rehabilitation Research Institute, Elkins Park, Pa. (Hart, Whyte); Department of Rehabilitation Medicine, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia (Hart).
Article Synopsis
- Memory impairments are a common issue after traumatic brain injury (TBI), and donepezil, a medication that helps with cognitive function, was evaluated for its effectiveness on these memory problems in a clinical trial called MEMRI-TBI-D.
- The study involved 75 participants with severe memory issues related to TBI, who were split into two groups: one receiving donepezil and the other a placebo over 10 weeks; results showed significant memory improvement in those taking donepezil.
- While donepezil was effective, it came with some side effects, notably diarrhea and nausea, and had a treatment-emergent adverse event rate of 46%, but overall, it demonstrated a favorable safety profile for treating memory impairments
Pharmacological intervention of behavioural traits and brain histopathology of prenatal valproic acid-induced mouse model of autism.
PLoS One
September 2024
School of Pharmacy, Brac University, Dhaka, Bangladesh.
Autism spectrum disorder (ASD) is one of the leading causes of distorted social communication, impaired speech, hyperactivity, anxiety, and stereotyped repetitive behaviour. The aetiology of ASD is complex; therefore, multiple drugs have been suggested to manage the symptoms. Studies with histamine H3 receptor (H3R) blockers and acetylcholinesterase (AchE) blockers are considered potential therapeutic agents for the management of various cognitive impairments.
View Article and Find Full Text PDFDual-target inhibitors based on acetylcholinesterase: Novel agents for Alzheimer's disease.
Eur J Med Chem
December 2024
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 105 Wenhua Road, Shenhe District, Shenyang, 110016, China. Electronic address:
Alzheimer's disease (AD) is the most common form of dementia among the elderly, accounting for 60 %-70 % of cases. At present, the pathogenesis of this condition remains unclear, but the hydrolysis of acetylcholine (ACh) is thought to play a role. Acetylcholinesterase (AChE) can break down ACh transmission from the presynaptic membrane and stop neurotransmitters' excitatory effect on the postsynaptic membrane, which plays a key role in nerve conduction.
View Article and Find Full Text PDFBuqi Huoxue Tongnao prescription protects against chronic cerebral hypoperfusion via regulating PI3K/AKT and LXRα/CYP7A1 signaling pathways.
Phytomedicine
September 2024
Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Peng Kang National Famous Traditional Chinese Medicine Expert Inheritance Studio, Southern Medicine University, Guangzhou 510315, China. Electronic address:
Background: Chronic cerebral hypoperfusion (CCH) has been confirmed as one of the pathogenesis underlying vascular cognitive impairment. A series of pathological changes, including inflammation, oxidative stress, and apoptosis, are involved in this pathophysiology and contribute to cognitive impairment and neuropathological alterations. The traditional Chinese medicine (TCM) of Buqi Huoxue Tongnao (BQHXTN) prescription possesses a remarkable clinical efficacy for treating patients with CCH, but still lacks a scientific foundation for its pharmacological mechanisms.
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