Selenium-75 (t1/2 = 120.4d; 100% EC) was prepared in no-carrier-added form by 22MeV proton-bombardment of natural arsenic(III) oxide powder held in a copper-aluminum drawer target (highest yield, 35 microCi/microAh; maximum current, 6 microA), followed by oxidation to [75Se]selenium(IV) oxide. No-carrier-added [75Se]5-ethoxycarbonyl-4-methyl-1,2,3-selenadiazole was prepared in one step from ethylacetoacetate semicarbazone with [75Se]selenium(IV) oxide in glacial acetic acid at 50 degrees C. Column chromatography of the final solution afforded the desired labeled compound in 30% yield and greater than 98% radiochemical purity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.apradiso.2003.11.091 | DOI Listing |
Publication Analysis
Top Keywords
[75se]seleniumiv oxide
8
synthesis [75se]5-ethoxycarbonyl-4-methyl-123-selenadiazole
4
[75se]5-ethoxycarbonyl-4-methyl-123-selenadiazole selenium-75
4
selenium-75 t1/2
4
t1/2 1204d
4
1204d 100%
4
100% prepared
4
prepared no-carrier-added
4
no-carrier-added form
4
form 22mev
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!