Results, prospects of studying the effects of ionizing radiation on human beings are considered with regard to the outcomes of the Chernobyl catastrophe and the results of a 5-year implementation of the All-Union Programme C-27. Present-day problems and approaches to investigation for the nearest 5-year period are formulated.
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Drug-drug interactions in metastatic hormone-sensitive prostate cancer (mHSPC): practical considerations for treating men with androgen receptor pathway inhibitors and common medications in this stage.
Expert Opin Drug Metab Toxicol
March 2025
Department of Pharmacy, Hospital Del Mar, Barcelona, Spain.
Introduction: New androgen receptor pathway inhibitors (ARPIs) are an essential part of the treatment strategy for patients with metastatic hormone-sensitive prostate cancer (mHSPC). Despite the good tolerability of ARPIs, after treatment is started, drug-drug interactions (DDIs) between these and other medications frequently taken by these patients may appear. DDIs may reduce the therapeutic effect of both and lead to increased adverse events.
View Article and Find Full Text PDFThe effect of gender role stress on psychological distress in pregnant women.
Appl Nurs Res
April 2025
Department of Nursing, Health Sciences Institute, Sakarya University, Serdivan, Sakarya, Turkey. Electronic address:
Aim: To examine the effect of gender role stress on psychological distress in pregnant women.
Background: Recognition and prevention of potential psychological as well as physiological adversities during pregnancy are critical in terms of reducing their impacts on mother and baby health and developing preventive health services.
Methods: This cross-sectional study was conducted with 182 volunteer pregnant women in Türkiye.
Advantages and challenges of ex vivo generation and expansion of human hematopoietic stem cells from pluripotent stem cells.
Exp Hematol
March 2025
Institute of Regenerative Medicine, and Department of Dermatology, Affiliated Hospital of Jiangsu University, Jiangsu University, 212001 Zhenjiang, Jiangsu, China; Haihe Laboratory of Cell Ecosystem, Institute of Hematology, Chinese Academy of Medical Sciences, 300020 Tianjin, China; Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, and South China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, 529020 Jiangmen, Guangdong, China; Division of Regenerative Medicine, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan; Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba 278-8510, Japan. Electronic address:
Hematopoietic stem cell transplantation (HSCT) is an essential and increasing therapeutic approach for treating conditions such as leukemia, lymphoma, and other blood cancers. However, its widespread use faces significant challenges, including limited donor availability, pathogen, and the risk of immune rejection. The emergence of pluripotent stem cells (PSCs) offers a potential solution to these challenges.
View Article and Find Full Text PDFDaily rumination and diurnal cortisol patterns in Latino adolescents: The moderating role of sex.
Psychoneuroendocrinology
February 2025
Department of Psychology, Arizona State University, USA.
Latinos make up the fastest-growing ethnic minority group in the United States and are at higher risk for the development of internalizing symptoms in adolescence than other ethnic groups. Rumination has been identified as a transdiagnostic risk factor associated with several internalizing disorders such as depression, anxiety, and comorbidities of the two. Indicators of risk for chronic stress and internalizing disorders can also be observed from the hypothalamic-pituitary-adrenal (HPA) axis (e.
View Article and Find Full Text PDFTwo-stage data augmentation for improved ASR performance for dysarthric speech.
Comput Biol Med
March 2025
Centre for Language and Speech Technology (CLST), Radboud University Nijmegen, The Netherlands; Centre for Language Studies (CLS), Radboud University Nijmegen, The Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands. Electronic address:
Machine learning (ML) and Deep Neural Networks (DNN) have greatly aided the problem of Automatic Speech Recognition (ASR). However, accurate ASR for dysarthric speech remains a serious challenge. The dearth of usable data remains a problem in applying ML and DNN techniques for dysarthric speech recognition.
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