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Ovarian and Uterine Morphology in Minipuberty: Associations with Reproductive Hormones. A COPANA Study of 302 girls.
J Clin Endocrinol Metab
September 2024
Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, 2100 Copenhagen O, Denmark.
Background: Female minipuberty is characterized by complex dynamics of circulating reproductive hormones, while the relationship between ovarian and uterine morphology and reproductive hormones remains to be elucidated.
Aim: To investigate the association between reproductive hormones and ovarian as well as uterine morphology by transabdominal ultrasound (TAUS) at minipuberty.
Methods: Secondary analysis from The Copenhagen Analgesic Study (COPANA) (ClinicalTrials.
Observations on the reproductive morphology of the female short-beaked echidna, Tachyglossus aculeatus.
J Anat
January 2025
School of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia.
Although monotremes diverged from the therian mammal lineage approximately 187 million years ago, they retain various plesiomorphic and/or reptilian-like anatomical and physiological characteristics. This study examined the morphology of juvenile and adult female reproductive tracts across various stages of the presumptive oestrous cycle, collected opportunistically from cadaver specimens submitted to wildlife hospitals during the breeding season. In adult females, ovaries had a convoluted cortex with follicles protruding from the ovarian surface.
View Article and Find Full Text PDFDifferential sensitivity to Wnt signaling gradients in human gastric organoids derived from corpus and antrum.
Am J Physiol Gastrointest Liver Physiol
August 2023
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Wnt signaling regulates gastric stem cell proliferation and differentiation. Although similar Wnt gradients exist within the corpus and antrum of the human stomach, there are striking differences in gland architecture and disease manifestation that suggest Wnt may differentially regulate progenitor cell function in each compartment. In this study, we tested sensitivities to Wnt activation in human gastric corpus and antral organoids to determine whether progenitor cells have region-specific differences in Wnt responsiveness.
View Article and Find Full Text PDFRole of spasmolytic polypeptide-expressing metaplasia in gastric mucosal diseases.
Am J Cancer Res
May 2023
Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University Zunyi, Guizhou, China.
Spasmolytic polypeptide-expressing metaplasia (SPEM) is a trefoil factor 2-expressing metaplasia in the fundic glands that resembles the fundic metaplasia of deep antral glandular cells and arises mainly from transdifferentiation of mature chief cells as well as mucous neck cells or isthmic stem cells. SPEM participates in the regulation of gastric mucosal injury, including focal and diffuse injury. This review focuses on the origin, models, and regulatory mechanisms of SPEM and on its role in the development of gastric mucosal injury.
View Article and Find Full Text PDFMorphometric features of gastric mucosa in atrophic gastritis: A different pattern between corpus and antrum.
Medicine (Baltimore)
April 2023
Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Atrophic gastritis can cause mucosa thinning, while detailed metrological evidence is lacking. We aimed to compare the morphological features of full-thickness gastric mucosa in antrum and corpus and evaluate the diagnostic performance for atrophy. Gastric cancer patients were prospectively enrolled (N = 401).
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