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Predictive factors of postoperative fentanyl consumption in patients with inflammatory bowel disease: a retrospective cohort study.
BMC Anesthesiol
March 2022
Department of Anesthesiology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Background: Patients with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, might present difficulties in achieving postoperative analgesia. Prior studies have suggested that patients with IBD undergoing major abdominal surgery require higher doses of perioperative opioids than do patients without IBD. Considering patients with IBD potentially require high-dose opioids, identifying those requiring higher opioid doses will allow clinicians to optimize the perioperative opioid dose and avoid insufficient pain management or complications of opioid overdose.
View Article and Find Full Text PDFPhysicochemical stability of nefopam and nefopam/droperidol solutions in polypropylene syringes for intensive care units.
Eur J Hosp Pharm
March 2020
Pharmacy, Centre Hospitalier Universitaire de Nancy, Vandoeuvre-lès-Nancy, France.
Introduction: Nefopam has been reported to be effective in postoperative pain control with an opioid-sparing effect, but the use of nefopam can lead to nausea and vomiting. To prevent these side effects, droperidol can be mixed with nefopam. In intensive care units, high concentrations of nefopam and droperidol in syringes can be used with a continuous flow.
View Article and Find Full Text PDFThe effect of anti-emetic drugs on rat embryonic heart activity.
Reprod Toxicol
August 2019
Discipline of Anatomy and Histology, Sydney School of Medical Science, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address:
Nausea and vomiting of pregnancy (NVP) is the most common medical complaint during pregnancy affecting up to 70% of pregnant women worldwide. Some antiemetic medications (AEM) (droperidol, domperidone, granisetron, metoclopramide and trifluoperazine) used to treat NVP have the unwanted side effect of hERG blockade. The hERG potassium channel is essential for normal heart rhythm in both the adult human and the human and rat embryo.
View Article and Find Full Text PDFThe pharmacokinetics of intranasal droperidol in volunteers characterised via population modelling.
SAGE Open Med
December 2018
Monash Emergency Research Collaborative, Department of Emergency Medicine, Dandenong Hospital, Monash Health, Dandenong, VIC, Australia.
Background: Droperidol is used parenterally to treat nausea and vomiting, migraine and acute behavioural disturbance. Intranasal use is not reported for droperidol. Intranasal drug administration reduces need for intravenous line placement and risk of needle-stick.
View Article and Find Full Text PDFParenteral Antipsychotic Choice and Its Association With Emergency Department Length of Stay for Acute Agitation Secondary to Alcohol Intoxication.
Acad Emerg Med
January 2019
Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, MN.
Background: Acute agitation secondary to alcohol intoxication frequently requires parenteral sedatives for patient and caregiver safety. Antipsychotics play a prominent role; however, no consensus exists regarding the ideal agent. One important consideration when evaluating the choice of antipsychotic is its association with emergency department (ED) length of stay (LOS).
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