OBJECTIVE:In this study that the DMBA was applicated to induce the premalignantal changes of the cheek pouches of 89 hamsters in various stage,the result was shown that the slight epithelial displasia was occured 3 weeks later,the medium displasia was occured 5 weeks later,and the severe displasia or the carcinoma in situ was occured 6-9 weeks later.It is suggested that the suitable experimental period of the hamster's carcinogenesis is during 1-3 weeks.
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Endosc Int Open
March 2024
Division of Gastroenterology, Shiga University of Medical Science, Otsu, Japan.
Several cases have been reported that suggest the efficacy of gel immersion endoscopic mucosal resection (GI-EMR) for gastric neoplasms. However, no study has evaluated treatment outcomes of GI-EMR for gastric neoplasms. This study aimed to investigate the efficacy and safety of GI-EMR for early gastric neoplasms.
View Article and Find Full Text PDFNeurocirugia (Astur : Engl Ed)
September 2022
Servicio de Neurocirugía, Complexo Hospitalario Universitario de Santiago, Santiago de Compostela, A Coruña, Spain.
McCune-Albright syndrome (MAS) is a rare heterogeneous genetic disorder that is characterized by a triad of polyostotic fibrous dysplasia (FD), café au lait spots (CAL), and multiple hyperfunctional endocrinopathies. In general, it is diagnosed clinically. From the triads, 2 of the findings are enough to make the diagnosis.
View Article and Find Full Text PDFDis Colon Rectum
June 2023
Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.
Background: Targeted ablation of anal canal high-grade dysplasia results in high recurrence over time. Circumferential radiofrequency ablation might decrease recurrence.
Objective: This study aimed to determine the safety and efficacy of circumferential radiofrequency ablation for anal high-grade dysplasia.
Dis Colon Rectum
December 2021
Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.
Background: Approximately 10% to 20% of patients with ulcerative colitis require surgery during their disease course, of which the most common is the staged restorative proctocolectomy with IPAA.
Objective: The aim was to compare the rates of anastomotic leaks among all staged restorative proctocolectomy with IPAA procedures.
Design: This was a retrospective cohort study.
Mol Syndromol
January 2020
Laboratório de Medicina Genômica, Centro de Genética Médica Dr. José Carlos Cabral de Almeida & Centro de Referência para Doenças Raras, IFF/FIOCRUZ, Rio de Janeiro, Brazil.
Cartilage-hair hypoplasia syndrome (CHH) is an autosomal recessive disorder caused by pathogenic variants of the gene and characterized by metaphyseal bone dysplasia associated with hypotrichosis, immunodeficiency, and predisposition to malignancy. However, the genotype-phenotype correlation in CHH is not well understood. Here, we report a single country cohort of 23 Brazilian patients with clinical and radiological features consistent with CHH.
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