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An Autocatalytic Platform Combining a Nonlinear Hybridization Chain Reaction and DNAzyme to Detect microRNA.
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December 2024
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
MicroRNAs (miRNAs) are small, non-coding RNAs that play pivotal roles in gene regulation; they are increasingly recognized as vital biomarkers for various diseases, notably cancer. Conventional methods for miRNA detection, such as quantitative PCR and microarray analysis, often entail intricate sample preparation and lack the requisite sensitivity to detect low-abundance miRNAs like miRNA-21. This protocol presents an innovative approach that combines branched hybridization chain reaction (bHCR) with DNAzyme technology for the precise detection of miRNA-21.
View Article and Find Full Text PDFOptimising Venturi flume oxygen transfer efficiency using uncertainty-aware decision trees.
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December 2024
Department of Civil Engineering, National Institute of Technology Kurukshetra, Haryana 136119, India.
This study optimizes standard oxygen transfer efficiency (SOTE) in Venturi flumes investigating the impact of key parameters such as discharge per unit width (), throat width (), throat length (), upstream entrance width (), and gauge readings ( and ). To achieve this, a comprehensive experimental dataset was analyzed using multiple linear regression (MLR), multiple nonlinear regression (MNLR), gradient boosting machine (GBM), extreme gradient boosting (XRT), random forest (RF), M5 (pruned and unpruned), random tree (RT), and reduced error pruning (REP). Model performance was evaluated based on key metrics: correlation coefficient (CC), root mean square error (RMSE), and mean absolute error (MAE).
View Article and Find Full Text PDFResonance frequency prediction of dielectric antennas for liquid sensing via support vector regression.
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Computer Engineering Department, Lorestan University, Khorramabad, Iran.
This paper presents a slot antenna integrated with a split ring resonator (SRR) and feed line, designed to achieve a high Q-factor while maximizing channel capacity utilization. By incorporating a lens into the dielectric resonator antenna (DRA), we enhance both bandwidth and directivity, with the dielectric material's permittivity serving as a key control parameter for radiation characteristics. We explore water and ethanol as controllable dielectrics within the terahertz (THz) frequency range (0.
View Article and Find Full Text PDFMulti-label classification to predict antibiotic resistance from raw clinical MALDI-TOF mass spectrometry data.
Sci Rep
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Department of Computer Sciences and Industries, Universidad Católica del Maule, Talca, Chile.
Antimicrobial resistance (AMR) poses a significant global health challenge, necessitating advanced predictive models to support clinical decision-making. In this study, we explore multi-label classification as a novel approach to predict antibiotic resistance across four clinically relevant bacteria: E. coli, S.
View Article and Find Full Text PDFBiomimetic fluorescence-enhanced platform based on photonic crystals and DNAzyme walker for visualization and quantification of miRNA-21.
Talanta
December 2024
Institute of Biomedical Precision Testing and Instrumentation, College of Artificial Intelligence, Taiyuan University of Technology, Taiyuan, Shanxi, 030600, PR China.
Developing a fluorescence sensing platform for point-of-care detection of low abundance biomarkers is highly valuable for early diagnosis of disease. Herein, a biomimetic fluorescence-enhanced platform based on photonic crystals and DNAzyme walker was constructed and further applied to visualize and quantify the miRNA-21 in biological samples. The DNAzyme walker was orthogonally activated by the target miRNA-21, which enabled the unlocking of the DNAzyme walker strand and the subsequently repeated substrate cleavage, thus generating enhanced fluorescence signals.
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