AI Article Synopsis
- The study monitored blood changes in rats given large amounts of alcohol compared to control rats receiving sugar over a period of 10 to 22 weeks.
- Alcohol consumption resulted in lower overall blood cell counts, including decreased red blood cells, hematocrit, and hemoglobin levels.
- Notably, while overall white blood cell counts dropped, there was an increase in neutrophils and a significant decrease in lymphocytes after alcohol ingestion.
Article Abstract
Hematological fluctuations following large alcohol oral administration (2 mL per animal per day) in rats were monitored at intervals ranging from 10 to 22 weeks and the findings were compared to those in control animals that were fed sucrose isocalorically. Following alcohol ingestion, there was a significant decrease in the total blood cellularity at all treatment intervals. A fall in the erythrocyte count per millimeter3 was accompanied by decreased hematocrit values and hemoglobin levels in the alcohol-treated animals. On the other hand, the MCV and MCH values were significantly elevated after alcohol ingestion. Despite overall leukopenia observed after alcohol ingestion, there was a significant increase in the absolute neutrophil count. The absolute lymphocyte count, however, fell significantly in the alcohol-treated animals. Eosinophils and basophils were not significantly altered by alcohol toxicity.
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