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Isolate Specific Transcriptome Changes Exerted by Isavuconazole Treatment in Candida auris.
Mycopathologia
December 2024
Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, Nagyerdei Krt. 98., Debrecen, 4032, Hungary.
The sudden emergence of multidrug- and pan-resistant Candida auris isolates, combined with limited treatment options, poses significant global challenges in healthcare settings. Combination based therapies are promising alternative options to overcome C. auris related infections, where echinocandin and isavuconazole (ISA) combinations may be an interesting and promising approach.
View Article and Find Full Text PDFLeaf traits and insect herbivory levels in two Mediterranean oaks and their hybrids through contrasting environmental gradients.
Tree Physiol
December 2024
Department of Ecology, Faculty of Biology, University of Salamanca, Salamanca 37071, Spain.
Insect herbivory has attracted enormous attention from researchers due to its effects on plant fitness. However, there remain questions such as what are the most important leaf traits that determine consumption levels, whether there are latitudinal gradients in herbivore pressure, or whether there are differences in susceptibility between hybrids and their parental species. In this work we address all these issues in two species of Mediterranean Quercus (Q.
View Article and Find Full Text PDFSelenium Enhances the Growth of Bovine Endometrial Stromal Cells by PI3K/AKT/GSK-3β and Wnt/β-Catenin Pathways.
Vet Sci
December 2024
College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
The bovine uterus is susceptible to bacterial infections after calving, particularly from (), which often results in endometritis. Additionally, postpartum stress in cows can elevate cortisol levels in the body, inhibiting endometrial regeneration and reducing immune function, thereby further increasing the risk of infection. Selenium (Se) is a common feed additive in dairy farming, known for its anti-inflammatory and antioxidant effects.
View Article and Find Full Text PDFResynthesis of Damaged Fe-S Cluster Proteins Protects Against Oxidative Stress in the Absence of Mn-Superoxide Dismutase.
J Fungi (Basel)
November 2024
Department of Molecular Biotechnology and Microbiology, Institute of Biotechnology, Faculty of Science and Technology, University of Debrecen, H-4032 Debrecen, Hungary.
The importance of manganese superoxide dismutase (Mn-SOD), an evolutionarily ancient metalloenzyme that maintains the integrity and function of mitochondria, was studied in oxidative stress-treated cultures. Deletion of the Mn-SOD gene () increased both the menadione sodium bisulfite (MSB)-elicited oxidative stress and the deferiprone (DFP)-induced iron limitation stress sensitivity of the strain. Moreover, DFP treatment enhanced the MSB sensitivity of both the gene deletion mutant and the reference strain.
View Article and Find Full Text PDFTranscriptome Analysis Provides Insights into the Safe Overwintering of Local Peach Flower Buds.
Curr Issues Mol Biol
December 2024
Institute of Fruit and Floriculture Research, Gansu Academy of Agricultural Sciences, Anning, Lanzhou 730070, China.
During the dormant period of peach trees in winter, flower buds exhibit weak cold resistance and are susceptible to freezing at low temperatures. Understanding the physiological and molecular mechanisms underlying the response of local peach buds to low-temperature adversity is crucial for ensuring normal flowering, fruiting, and yield. In this study, the experimental materials included the conventional cultivar 'Xia cui' (XC) and the cold-resistant local resources 'Ding jiaba' (DJB) peach buds.
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