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Central Hypothyroidism with Low TSH Compared to Normal TSH Is Associated with More Advanced Pituitary Disease and Less Favorable Metabolic Profile.
Metabolites
February 2025
Department of Endocrinology and Metabolic Diseases, Medical University of Łódź, Rzgowska 281/289, 93-338 Łódź, Poland.
Central hypothyroidism is characterized by either decreased TSH or, more commonly, normal TSH. This study aims to check whether this biochemical difference related to the severity of the pituitary disease, metabolic processes and general well-being. A retrospective analysis was performed on 108 inpatients with hypopituitarism, aged 18-80, hospitalized (1 January 2020, through 31 December 2022) in the Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Poland.
View Article and Find Full Text PDFReplacement with sex steroids in hypopituitary men and women: implications for gender differences in morbidities and mortality.
Rev Endocr Metab Disord
October 2024
Department of Endocrinology, Beaumont Hospital, Royal College of Surgeons of Ireland, Dublin 9, Dublin, Ireland.
Article Synopsis
- Hypopituitarism is a disorder marked by low levels of one or more anterior pituitary hormones, with notable differences in health outcomes between sexes; women experience higher rates of cardiovascular issues and higher mortality.
- The dysfunction of the hypothalamic-pituitary-gonadal (HPG) axis leads to hormonal deficiencies (like estrogen and testosterone), and treating these deficiencies with hormone replacement therapy is crucial for health benefits.
- Despite the positive effects of hormone replacement in reducing mortality risk, the reasons behind the sex disparities in health outcomes for hypopituitarism patients remain unclear, with possibilities including lack of aggressive treatment for women and premature loss of protective estrogen effects.
Special features on insulin resistance, metabolic syndrome and vascular complications in hypopituitary patients.
Rev Endocr Metab Disord
June 2024
Endocrinology Division, Department of Clinical Medicine, Faculdade de Ciências Médicas, Departamento de Clínica Médica, Disciplina de Endocrinologia, Universidade Estadual de Campinas. Rua Tessália Vieira de Camargo, 126, Barão Geraldo, CEP 13083-887, Campinas, São Paulo, Brasil.
Pituitary hormone deficiency, hypopituitarism, is a dysfunction resulting from numerous etiologies, which can be complete or partial, and is therefore heterogeneous. This heterogeneity makes it difficult to interpret the results of scientific studies with these patients.Adequate treatment of etiologies and up-to-date hormone replacement have improved morbidity and mortality rates in patients with hypopituitarism.
View Article and Find Full Text PDF[Multidisciplinary efforts to improve the diagnosis and treatment of cirrhosis due to anterior pituitary hypopituitarism].
Zhonghua Yi Xue Za Zhi
January 2024
National Health Commission, Key Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.
More and more clinical evidence confirms that hypopituitary dysfunction can lead to liver cirrhosis. The causes of hypopituitary dysfunction include sellarneoplastic diseases, hereditary diseases, perinatal adverse events, etc. Clinically, growth hormone deficiency (GHD) often the first cause in hypopituitary dysfunction.
View Article and Find Full Text PDFAndrogen deficiency in hypopituitary women: its consequences and management.
Rev Endocr Metab Disord
June 2024
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gröna Stråket 8, Gothenburg, 41345, Sweden.
Women with hypopituitarism have various degrees of androgen deficiency, which is marked among those with combined hypogonadotrophic hypogonadism and secondary adrenal insufficiency. The consequences of androgen deficiency and the effects of androgen replacement therapy have not been fully elucidated. While an impact of androgen deficiency on outcomes such as bone mineral density, quality of life, and sexual function is plausible, the available evidence is limited.
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