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Performance of the World Health Organization (WHO) severe acute respiratory infection (SARI) case definitions in hospitalized children and youth: cross-sectional study.
Lancet Reg Health Am
April 2025
Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Ontario, Canada.
Background: Respiratory tract infections with viral pathogens are frequently identified using the World Health Organization (WHO) case definition of severe acute respiratory infection (SARI), defined as fever of ≥38°Celsius, cough, onset within 10 days, and hospitalization. While there is extensive research in adults, less is known about the WHO SARI case definition performance in children and youth. We aimed to determine the performance of the WHO SARI and modified case definitions in identifying viral respiratory tract infections in hospitalized children and youth.
View Article and Find Full Text PDFMonte Carlo simulation to optimize polymyxin B dosing regimens for the treatment of Gram-negative bacteremia.
Front Cell Infect Microbiol
March 2025
Department of Pharmacy, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, China.
Objective: This study aimed to predict and evaluate the efficacy of various polymyxin B dosing regimens for Gram-negative bacteremia using Monte Carlo simulation, with a specific focus on assessing the efficacy in patients receiving continuous renal replacement therapy (CRRT). The goal was to optimize clinical dosing regimens and guide rational polymyxin B use in practice.
Methods: A total of 1,939 Gram-negative bacterial strains were analyzed, collected between April 2019 and December 2021 through the China Bloodstream Gram-negative Pathogens Antimicrobial Resistance and Virulence Surveillance Network (CARVIS-NET).
Maternal Hyperandrogenemia and the Long-Term Neuropsychological, Sex Developmental, and Metabolic Effects on Offspring.
Int J Mol Sci
February 2025
2nd Department of Obstetrics and Gynaecology, Aretaieio Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Maternal hormonal and metabolic disorders, such as diabetes and obesity, can adversely affect the intrauterine environment, resulting in suboptimal fetal growth and an elevated risk of cardiovascular and metabolic diseases in the later life of the offspring. In this review, we examine the long-term impact of elevated maternal androgen levels during pregnancy on offspring. Maternal hyperandrogenemia is linked to various neurodevelopmental disorders, including attention-deficit/hyperactivity disorder, autism spectrum disorder, and anxiety-like behaviors, mediated by alterations in key brain regions responsible for emotion and cognition.
View Article and Find Full Text PDFThe Final Rule in a Bind: What We Are Learning From Suboptimal Simultaneous Heart-Kidney Outcomes and Potential Solutions to the Problem.
Transplantation
November 2024
Division of Nephrology, University of Arizona, Tucson, AZ.
Background: The 2018 revision of the adult Heart Allocation Policy (aHAP) led to a notable increase in the rate of simultaneous heart-kidney transplants (SHKT) in the United States. However, this policy has faced criticism for its inability to enhance post-transplant survival rates or decrease mortality among SHKT recipients on the waitlist, although high-quality kidneys are used.
Methods: We analyzed data from the Organ Procurement and Transplantation Network, covering 1549 SHKT cases from 2015 to 2021.
3D Soft Liquid Metal Electrodes for High-Resolution and Long-Term Electromyography in Muscle Trauma Assessment.
Adv Mater
March 2025
Department of Materials Science & Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
Electromyography (EMG) is a widely used diagnostic technique for evaluating the electrical activity of muscles and their controlling nerves. However, conventional surface electrodes with planar structures often suffer from low spatial resolution and suboptimal signal quality. Here, 3D-shaped, substrate-free, soft, and biocompatible liquid metal electrodes (LMe) are presented as a wearable interface for neuromuscular signal recording.
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