AI Article Synopsis
- The text explores how maternal infection and prolonged bed rest can worsen health outcomes in pregnant women with a homozygous Leiden mutation, potentially leading to complications like prematurity and deep-vein thrombosis.
- It highlights a specific case where these factors contributed to health issues in both the mother and her premature baby, who had a heterozygous genetic mutation.
- The baby is identified as being at increased risk for intracranial hemorrhage due to having at least one copy of the faulty factor V Leiden allele.
Article Abstract
The possible etiologic roles of infection and bed rest are discussed in connection with a case of maternal homozygous Leiden mutation leading to prematurity, maternal deep-vein thrombosis and neonatal intracranial hemorrhage in a heterozygous premature baby. Maternal bacterial infection and bed rest may trigger deep-vein femoral thrombosis in women with a homozygous Leiden mutation on tocolytic therapy for the treatment of premature labor. The neonate carrying at least one mutated allele of factor V Leiden might be at risk for the development of intracranial hemorrhage.
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| http://dx.doi.org/10.1159/000076711 | DOI Listing |
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