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Similar Publications
Thiazolidinediones, peripheral edema, and type 2 diabetes: incidence, pathophysiology, and clinical implications.
Endocr Pract
April 2004
Section of Diabetes and Metabolism, VA San Diego HealthCare System, California 92161, USA.
Objective: To present an objective, evidence-based review of edema associated with thiazolidinedione use in patients with type 2 diabetes.
Methods: We review the incidence, pathophysiology, and clinical significance of edema associated with the use of thiazolidinediones, with specific emphasis on the two currently available thiazolidinediones, rosiglitazone and pioglitazone.
Results: Both pioglitazone and rosiglitazone have been associated with increased development of edema in clinical trials.
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