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The ins and outs of liver fat metabolism: The effect of phenotype and diet on risk of intrahepatic triglyceride accumulation.
Exp Physiol
January 2025
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
In health, the liver is a metabolically flexible organ that plays a key role in regulating systemic lipid and glucose concentrations. There is a constant flux of fatty acids (FAs) to the liver from multiple sources, including adipose tissue, dietary, endogenously synthesized from non-lipid precursors, intrahepatic lipid droplets and recycling of triglyceride-rich remnants. Within the liver, FAs are used for triglyceride synthesis, which can be oxidized, stored or secreted in very low-density lipoproteins into the systemic circulation.
View Article and Find Full Text PDFThe ins and outs of spinal cord stimulation.
Brain Commun
January 2025
Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.
This scientific commentary refers to 'Intraspinal microstimulation of the ventral horn has therapeutically relevant cross-modal effects on nociception', by Bandres . (https://doi.org/10.
View Article and Find Full Text PDFA Mnemonic for Effective "Lesss PAINFUL" Pre-Rounding.
Cureus
December 2024
Radiology, University of California Davis School of Medicine, Sacramento, USA.
Due to much of medical training being inpatient centered, medical trainees generally do more pre-rounding on a per-patient basis than they do complete histories and physical exams (H&Ps). However, formal training often overlooks pre-rounding as a critical aspect of medical education and patient care, with at least 10 times more publications on H&Ps than on any other aspect of rounding over the past half-century. To address this critical gap in medical education, we introduce the "Lesss PAINFUL" pre-rounding mnemonic, emphasizing the importance of efficient pre-rounding for medical students or other trainees.
View Article and Find Full Text PDFThe "Ins and Outs and What-Abouts" of H2A.Z: A tribute to C. David Allis.
J Biol Chem
January 2025
Institute for Genetics, Justus-Liebig-University Giessen, Giessen, Germany. Electronic address:
In 2023, the brilliant chromatin biologist C. David Allis passed away leaving a large void in the scientific community and broken hearts in his family and friends. With this review, we want to tribute Dave's enduring inspiration by focusing on the histone variant H2A.
View Article and Find Full Text PDFCross-cultural adaptation and validation of Dysphagia Handicap Index in Bangladesh.
J Patient Rep Outcomes
January 2025
Department of SLT, Bangladesh Health Professions Institute (BHPI), CRP, Dhaka, Bangladesh.
The Dysphagia Handicap Index (DHI) is commonly utilized for evaluating how dysphagia impacts the quality of life (QoL) of patients across physical, functional, and emotional dimensions. The primary aim of the research was to linguistically validate and culturally adapt the DHI to the Bangla version. A cross-sectional study design was chosen, with Beaton's protocol as the guiding framework for validating and adapting the DHI.
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