Background: Dental caries is a widespread disease. It causes irreversible damage, pain and considerable expense. Fluoride is the only known substance that raises the tooth's resistance to acid attack. Natural drinking waters contain fluoride at different concentration. The most effective method of fluoride administration to the community level is by adjustng the fluoride concentration in the drinking water to about 1 part per million.
Aim: To describe the mode of action of fluoride, methods of administration and to describe water fluoridation, advantages and disadvantages.
Results: Fluoridation of drinking water started in 1945 in the world and in 1981 in Israel. Today more then 300 million people in some 60 countries enjoy the defending effect of fluoride in drinking water. This is the most effective method for decreasing incidence of caries, as well as being cost effective. Over the years there were many attempts to 'blame' fluoridation with negative side effects to human health. Till today, none of the allegations passed scientific scrutiny.
Conclusions: There is overwhelming scientific support for the Regulations that oblige the Water supplier to adjust fluoride levels to 1 ppm in every town or municipality with more then 5,000 inhabitants.
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Environ Sci Pollut Res Int
January 2025
ANSES, Nancy Laboratory for Hydrology, Water Chemistry Department, 40 Rue Lionnois, 54000, Nancy, France.
Pesticide transformation products (TPs) are frequently quantified in aquatic systems, including surface and groundwater. They often present higher polarity than parent compounds, are less volatile and less biodegradable and are therefore more mobile and persistent. These properties make them compounds of main interest in water resources and drinking water.
View Article and Find Full Text PDFAm J Pathol
January 2025
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA; Department of Internal Medicine, Division of Gastroenterology, Hepatology & Mobility, University of Kansas Medical Center, Kansas City, Kansas 66160, USA. Electronic address:
Alcohol-associated liver disease (ALD) is a significant global health concern and a leading cause of liver disease-related deaths. However, the treatment options are limited due to the lack of animal models that accurately replicate ALD pathogenesis. An ideal ALD animal model should have pathological characteristics similar to those of human ALD, with a clear pathological process and ease of drug intervention.
View Article and Find Full Text PDFChemosphere
January 2025
Department of Civil and Environmental Engineering, National University of Singapore, 1 Engineering Drive 2, 117576, Singapore; NUS Environmental Research Institute, National University of Singapore, 5A Engineering Drive 1, 117411, Singapore. Electronic address:
Drinking water distribution systems face a multifaceted emerging concern, including in situ microplastic (MP) generation, chemical leaching from plastic pipes, and the formation of disinfection by-products (DBPs). This study investigated the co-release of MPs and chemical leachates from polyvinyl chloride (PVC) pipes exposed to different chlorine concentrations on a lab scale, as well as the subsequent formation of DBP. Results highlighted significant evidence of PVC-derived dissolved organic matter (PVC-DOM) and microplastic (PVC-MP) leaching at higher chlorine concentrations.
View Article and Find Full Text PDFPLoS One
January 2025
School of Medicine, Institute of Health Science, Jigjiga University, Jigjiga, Ethiopia.
Background: One of the tropical illnesses that is often overlooked is soil-transmitted helminths, or STHs. In tropical and subtropical nations, where poor sanitation and contaminated water sources are common, they mostly impact the most vulnerable populations.
Objective: The aim of this study was to ascertain the prevalence of STHs and related risk factors among the people living in Jigjiga town, Somali region, Eastern Ethiopia.
Anal Chem
January 2025
Center for Devices and Radiological Health, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, United States.
Non-targeted analysis (NTA) using high-resolution mass spectrometry without defined chemical targets has the potential to expand and improve chemical monitoring in many fields. Despite rapid advancements within the research community, NTA methods and data remain underutilized by many potential beneficiaries. To better understand barriers toward widespread adoption, the Best Practices for Non-Targeted Analysis (BP4NTA) working group conducted focus group meetings and follow-up surveys with scientists (n = 61) from various sectors (e.
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