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Stereotactic Radiosurgery Dose Reduction for Melanoma Brain Metastases Patients on Immunotherapy or Target Therapy: A Single-Center Experience.
Neurosurgery
October 2024
Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA.
Background And Objectives: Better local control but higher rates of adverse radiation events (ARE) have been reported when combining American Society for Radiation Oncology (ASTRO)-guideline-suggested dose (SD) stereotactic radiosurgery (SRS) with immunotherapy or targeted therapy for melanoma brain metastases. The objective of this study is to explore the efficacy and safety of lower prescription doses compared with ASTRO guidelines for single-fraction SRS for patients with melanoma metastases who are concurrently receiving immunotherapy or targeted therapy.
Methods: We conducted a retrospective, single-center study on 194 patients who underwent SRS between 2009 and 2022.
Investigation of Phosphazene Superbase Interactions with [PClN].
Inorg Chem
October 2024
Department of Chemistry, The University of Akron, Akron, Ohio 44325, United States.
In this study, the reaction between phosphazene superbases and a chlorophosphazene trimer ([PClN]) has been investigated. In this room temperature reaction, the phosphazene superbase (MeN)PN(MeN)P═NEt, commonly known as PEt, was shown to behave as a nucleophile, displacing one of the chlorides from [PClN] and producing the tadpole-like structure . The reaction described herein is one of the few instances of a phosphazene superbase behaving as a nucleophile rather than a Brønsted base.
View Article and Find Full Text PDFPrevalence and Risk Factors of Constipation Symptoms among Patients Undergoing Colonoscopy: A Single-Center Cross-Sectional Study.
Digestion
August 2024
Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.
Introduction: Constipation is one of the most common gastrointestinal symptoms. It may compromise quality of life and social functioning and result in increased healthcare use and costs. We aimed to evaluate the prevalence and risk factors of constipation symptoms, as well as those of refractory constipation symptoms among patients who underwent colonoscopy.
View Article and Find Full Text PDFFar-reaching effects of tyrosine64 phosphorylation on Ras revealed with BeF complexes.
Commun Chem
January 2024
School of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK.
Tyrosine phosphorylation on Ras by Src kinase is known to uncouple Ras from upstream regulation and downstream communication. However, the mechanisms by which phosphorylation modulates these interactions have not been detailed. Here, the major mono-phosphorylation level on tyrosine64 is quantified by P NMR and mutagenesis.
View Article and Find Full Text PDFProspective monitoring of adverse events following vaccination with Modified vaccinia Ankara - Bavarian Nordic (MVA-BN) administered to a Canadian population at risk of Mpox: A Canadian Immunization Research Network study.
Vaccine
January 2024
Canadian National Vaccine Safety Network (CANVAS); Vaccine Evaluation Center, BC Children's Hospital Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, Canada.
MVA-BN is an orthopoxvirus vaccine that provides protection against both smallpox and mpox. In June 2022, Canada launched a publicly-funded vaccination campaign to offer MVA-BN to at-risk populations including men who have sex with men (MSM) and sex workers. The safety of MVA-BN has not been assessed in this context.
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