The regional elastic properties analysis of myocardium based on echocardiographic 3-D reconstruction of the left ventricle.

The present study evaluates the myocardium regional elastic properties on the basis of relative thickness change (DeltaHWT) in the left ventricular (LV) wall during the diastolic filling phase. Two-dimensional (2-D) LV long-axis images were obtained with a Powervision-380 (Toshiba) transesophageal echocardiographic imager. Three-dimensional (3-D) reconstruction of the LV was carried out by rotation of the transducer in calibrated steps. Endocardial and epicardial surfaces were approximated to the shape of heart wall by means of spherical functions. At the beginning of the diastolic filling phase, LV endocardial surface was divided into equal angular segments sized about 4 x 4 mm in a spherical coordinate system. To define the displacement direction of the heart wall surface fragments at every moment (frame) of diastolic filling, a new algorithm was developed. The elastic properties of LV wall regions were represented as regional DeltaHWT maps. A qualitative test of the method was implemented according to data from clinical and instrumental inspections of the patients with ischemic heart disease (IHD). Possible error sources were considered to evaluate the method quantitatively. The method root-mean-square error was about 5.4%, including errors of initial data, approximation and rounding off.