Evolution of bovine viral diarrhea virus vaccines.

Vet Clin North Am Food Anim Pract

Department of Veterinary and Biomedical Sciences, University of Nebraska, 124 Veterinary Diagnositc Center, Lincoln, NE 68583-0905, USA.

Published: March 2004

AI Article Synopsis

  • Control of BVDV is crucial for the cattle industry since it causes diseases that lead to production losses, especially in reproductive health and calf immunity.
  • Effective control involves herd health programs that limit exposure to persistently infected (PI) cattle and optimize immunity through vaccination.
  • Vaccination alone cannot fully prevent fetal infections or losses, so a combination of vaccination and management practices is necessary to identify and eliminate PI carriers and reduce BVDV exposure.

Article Abstract

Control of bovine viral diarrhea virus (BVDV) infection is economically important to the cattle industry because the virus causes a variety of clinical diseases that adversely affect essentially all stages of the production cycle. Production losses primarily stem from reproductive failure and from immunosuppression during acute BVDV infection, which predisposes calves to respiratory or enteric diseases. Control is achieved by implementing herd health pro-grams focused on limiting exposure by avoiding persistently infected (PI) carrier cattle and by optimizing protective immunity through immunization. Vaccination cannot be relied upon solely to protect against fetal infection and losses due to BVD. This is because no single BVDV vaccine has been shown to give complete fetal protection. In addition to strategic use of vaccines, herd management practices should also be implemented to identify and eliminate PI carrier cattle and to avoid exposure to BVDV infection.

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Source
http://dx.doi.org/10.1016/j.cvfa.2003.11.001DOI Listing

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