Objective: To investigate the stress distribution in the mandibular fixed partial denture (FPD) by changing the length of pontics.
Methods: Based on a 3-DFE model of the mandibular FPD, we analyzed the stress distribution in the mandibular FPDs by loading the same level force at pontics with different lengths that were 2 to 4 times of normal length.
Results: The distribution trends of the stresses in the mandibular FPDs with differently elongated pontics were similar, but the highest von Mises stress in the bridge was enlarged.
Conclusion: Damages may develop in the mandibular FDP, when the length of the pontic is longer than 3 times of normal length.
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mBio
January 2025
Analytical Biochemistry and Proteomics Unit, Instituto de Investigaciones Biológicas Clemente Estable and Institut Pasteur de Montevideo, Montevideo, Uruguay.
Unlabelled: Mycobacteria, including pathogens like , exhibit unique growth patterns and cell envelope structures that challenge our understanding of bacterial physiology. This study sheds light on FhaA, a conserved protein in , revealing its pivotal role in coordinating cell envelope biogenesis and asymmetric growth. The elucidation of the FhaA interactome in living mycobacterial cells reveals its participation in the protein network orchestrating cell envelope biogenesis and cell elongation/division.
View Article and Find Full Text PDFFront Plant Sci
January 2025
College of Agriculture, Shihezi University, Shihezi, China.
Introduction: In order to elucidate the physiological mechanism of post-flowering assimilate transport regulating the formation of yields in arid regions and to provide technological support for further water-saving and high yields in the wheat region in Xinjiang, we conducted a study on the effects of different fertility periods and different degrees of drought and re-watering on the post-flowering dry matter accumulation and transport of spring wheat and the characteristics of grain filling.
Methods: In two spring wheat growing seasons in 2023 and 2024, a split-zone design was used, with the drought-sensitive variety Xinchun 22 (XC22) and drought-tolerant variety Xinchun 6 (XC6) as the main zones and a fully irrigated control during the reproductive period [CK, 75%~80% field capacity (FC)], with mild drought at the tillering stage (T1, 60%~65% FC), moderate drought at the tillering stage (T2, 45%~50% FC), mild drought at the jointing stage (J1, 60%~65% FC), and mild drought at the jointing stage (J2, 45%~50% FC) as the sub-zones.
Results: The dry matter accumulation of the aboveground parts of wheat (stem sheaths, leaves, and spikes), the transfer rate and contribution rate of nutrient organs, the maximum filling rate (V), and the mean filling rate (V) increased significantly after re-watering in the T1 treatment, and decreased with the deepening of the degree of water stress.
Front Bioeng Biotechnol
January 2025
Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Iliac Vein Compression Syndrome (IVCS) is a common risk factor for deep vein thrombosis in the lower extremities. The objective of this study was to investigate whether employing a porous medium model to simulate the compressed region of an iliac vein could improve the reliability and accuracy of Computational Fluid Dynamics (CFD) analysis outcomes of IVCS. Pre-operative Computed Tomography (CT) scan images of patients with IVCS were utilized to reconstruct models illustrating both the compression and collateral circulation of the iliac vein.
View Article and Find Full Text PDFClin Exp Dent Res
February 2025
Dental Research Center, Dentistry Research Institue and Department of Prosthodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Objectives: To assess the effect of occlusion and implant number/position on stress distribution in Kennedy Class II implant-assisted removable partial denture (IARPD).
Materials And Methods: IARPDs were designed in six models: with one implant (bone level with a platform of 4 mm and length of 10 mm) at the site of (I) canine, (II) between first and second premolars, (III) first molar, (IV) second molar, or two implants at the sites of (V) canine-first molar, and (VI) canine-second molar. A conventional RPD served as control.
Prog Neuropsychopharmacol Biol Psychiatry
January 2025
Louisiana State University, Department of Comparative Biomedical Sciences, Baton Rouge, LA 70803, United States of America. Electronic address:
Renewed interest in the clinical use of psychedelic drugs acknowledges their therapeutic effectiveness. It has also provided a changing frame of reference for older psychedelic drug study data, especially regarding concentrations of N, N-dimethyltryptamine (DMT) reported in rodent brains and recent discoveries in DMT receptor interactions in rat brain neurons and select brain areas. The mode of action of DMT in its newly defined role as a neuroplastogen, its effectiveness in treating neuropsychiatric disorders, and its binding to intracellular sigma-1 and 5HT2a receptors may define these possible roles.
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