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Are oligodendrocytes bystanders or drivers of Parkinson's disease pathology?
PLoS Biol
January 2025
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
The major pathological feature of Parkinson 's disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons in the substantia nigra, a part of the midbrain. Despite decades of research, the molecular mechanisms of the origin of the disease remain unknown. While the disease was initially viewed as a purely neuronal disorder, results from single-cell transcriptomics have suggested that oligodendrocytes may play an important role in the early stages of Parkinson's.
View Article and Find Full Text PDFLeft Atrial Enlargement in Primary Cryptogenic Strokes Without Atrial Fibrillation.
Cureus
December 2024
Cardiovascular Disease, HCA Houston Healthcare, Kingwood, USA.
The relationship between left atrial enlargement (LAE) and primary cryptogenic stroke (PCS) remains a mystery. LAE has been proposed to be an independent risk factor of PCS, recurrent ischemic strokes, paroxysmal atrial fibrillation, and thromboembolism. Our study evaluates the prevalence of LAE among patients with PCS in the absence of atrial fibrillation, unlike previous studies that included atrial fibrillation, in order to isolate LAE as a risk factor.
View Article and Find Full Text PDFHow a medical mystery led to a cure for viral hepatitis.
Nat Med
January 2025
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Diagnostic enigma of pulmonary hypertension: Tale from a series of three patients.
Med J Armed Forces India
December 2024
Consultant (Radiodiagnosis), Medica Super Specialty Hospital, Kolkata, India.
Pulmonary hypertension (PH) is a complex condition with multiple etiological factors. The ability to identify a potential underlying cause is crucial for accurate diagnosis, patient management, and prognostication. This article presents a series of three patient cases to illustrate the enigmatic nature of PH diagnosis.
View Article and Find Full Text PDFCatching up with creeping fat - unravelling the mysteries of the mesentery in Crohn's disease.
Gastroenterology
December 2024
Guangdong Provincial Key Laboratory of Gastroenterology Institute of Gastroenterology of Guangdong Province Department of Gastroenterology, Nanfang Hospital Southern Medical University, Guangzhou, China.
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