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Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: A Novel Approach for Anti-Inflammatory Wound Dressings.
Pharmaceutics
April 2024
JeNaCell GmbH-An Evonik Company, 07745 Jena, Germany.
The effective pharmacological treatment of inflamed wounds such as pyoderma gangraenosum remains challenging, as the systemic application of suitable drugs such as glucocorticoids is compromised by severe side effects and the inherent difficulties of wounds as drug targets. Furthermore, conventional semi-solid formulations are not suitable for direct application to open wounds. Thus, the treatment of inflamed wounds could considerably benefit from the development of active wound dressings for the topical administration of anti-inflammatory drugs.
View Article and Find Full Text PDFPAPA Syndrome: Challenges in Achieving Long-Term Remission.
Acta Dermatovenerol Croat
November 2023
Professor Asja Prohić, MD, PhD, Department of Dermatovenerology, Sarajevo Medical School, University Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina;
Article Synopsis
- PAPA syndrome is an autoinflammatory condition caused by mutations in the PSTPIP1 gene, leading to symptoms like pyogenic arthritis, pyoderma gangrenosum, and acne due to abnormal inflammasome activation.
- The syndrome results in increased production of interleukin-1β and other pro-inflammatory cytokines, disrupting the body's inflammatory response.
- Current treatments focus on corticosteroids and biologics that inhibit IL-1 and TNF-α, addressing the underlying inflammation and helping manage symptoms effectively.
Detection of a rare variant in PSTPIP1 through three generations in a family with an initial diagnosis of FMF/MKD-overlapping phenotype.
Rheumatology (Oxford)
September 2023
Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Acıbadem University, Istanbul, Turkey.
Objective: The presence of FMF cases without MEFV (MEFV innate immunity regulator, pyrin) pathogenic variants led us to search for other genes' involvement in the disease development. Here, we describe the presence of genetic heterogeneity in a three-generation family with an FMF/mevalonate kinase deficiency (MKD)-overlapping phenotype without MEFV/MVK (mevalonate kinase) pathogenic variants.
Method: Targeted sequencing revealed a rare, fully penetrant variant in PSTPIP1 (p.
Refractory Pyoderma Gangrenosum: Stabilized on Colchicine and Tumor Necrosis Factor (TNF) Inhibitor.
Cureus
October 2022
Department of Dermatology, University of Tabuk, Tabuk, SAU.
Pyoderma gangrenosum (PG) is a rare ulcerative, painful inflammatory skin condition that is categorized among neutrophilic dermatoses. We report an otherwise healthy female who initially presented to a dermatology clinic with erythematous nodules and pustules scattered over her legs and thigh, which progressed later to multiple painful ulcers. Upon further investigation, it was diagnosed as idiopathic PG.
View Article and Find Full Text PDFPyoderma gangrenosum (PG) is an uncommon inflammatory neutrophilic disorder with a spectrum of clinical presentations with variable courses. Most cases are associated with an autoimmune disorder and manifest in middle-aged adults as a painful lesion that progresses to painful necrotizing ulcers of the lower extremity. Owing to its variability, clinical diagnosis remains difficult and many patients are often misdiagnosed, with resulting delay in treatment.
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