Olfactory bulbectomy (OBX) in rats produces behavioral, physiological, and neurochemical changes that resemble symptoms of depression in humans. The procedure thus serves as a rodent model of affective disorder. Many of the behavioral effects of OBX resemble psychomotor agitation. The possible role of dysregulation of ventral striatal dopamine (DA) systems in this phenomenon was investigated. Basal levels of DA, norepinephrine (NE), homovanillic acid, dihydroxyphenylacetic acid, and 5-hydroxyindoleacetic acid were examined in the striatum of OBX and sham-operated controls using in vivo microdialysis. OBX rats exhibited significantly higher basal DA levels (192%) and lower NE levels (12%) than sham-operated controls. Locomotor activity in response to novelty and footshock stress was elevated in OBX rats. The finding of higher DA levels in striatum may explain this "agitation-like" behavior, a commonly observed phenomenon in the OBX model.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.physbeh.2004.01.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Empagliflozin ameliorates olfactory bulbectomy-induced depression by mitigating oxidative stress and possible involvement of brain derived neurotrophic factor in diabetic rats.
Int J Neurosci
October 2024
Department of Pharmacology, Rajarshi Shahu College of Pharmacy, Buldana, India.
Article Synopsis
- Empagliflozin, an SGLT2 inhibitor, was tested for its antidepressant effects in diabetic rats using a model that simulates neuroinflammation-mediated depression after performing olfactory bulbectomy (OBX) surgery.
- The study involved treating the rats with oral doses of empagliflozin, metformin, and clomipramine over 14 days, and measuring changes in behavior and antioxidant levels.
- Results indicated that empagliflozin improved depressive behaviors and restored antioxidant levels in the brain, suggesting it may help treat depression linked to neuroinflammation and oxidative stress.
Antidepressant-like effects of Jieyu Chufan capsules in the olfactory bulbectomy rat model.
Brain Res
February 2024
Hebei Medical University, No. 361, East Zhongshan Road, Shijiazhuang 050017, Hebei, China; National Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang 050035, China. Electronic address:
The olfactory bulbectomy (OBX) animal model of depression reproduces the behavioral and neurochemical changes observed in depressed patients. We assessed the therapeutic effects of the Jieyu Chufan (JYCF) capsule on OBX rats. JYCF ameliorated the hedonic and anxiety-like behavior of OBX rats and attenuated the cortical and hippocampal damage.
View Article and Find Full Text PDFNeonatal olfactory bulbectomy causes dendritic spine retraction in dorsal hippocampal CA3 neurons in female rats and spatial learning deficits in male rats.
Brain Struct Funct
January 2024
Laboratorio de Neurofisiología Experimental, Facultad de Ciencias Biológicas, Benemérita Universidad Autónoma de Puebla, Edificio BIO1, Ciudad Universitaria, CP, 72570, Puebla, Puebla, México.
Olfactory bulbectomy (OBX) is an experimental strategy that is widely employed because it produces changes at different levels (from behavioral to molecular) that can be related to symptoms of depression in humans. This procedure has been widely studied in adult rats, but little information has been obtained of its effect in neonatal rats. The objective of the present study was to evaluate learning and memory capacity and dendritic spine density in dorsal hippocampal CA3 neurons.
View Article and Find Full Text PDFOlfactory Bulbectomy Model of Depression Lowers Responding for Food in Male and Female Rats: The Modulating Role of Caloric Restriction and Response Requirement.
Biomedicines
September 2023
Department of Pharmacology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic.
Depression is a psychiatric disorder characterized by a marked decrease in reward sensitivity. By using the olfactory bulbectomy (OBX) model of depression, it was shown that OBX rats display enhanced drug-taking and seeking behaviors in a self-administration paradigm than sham-operated (SHAM) controls, and sex is an important regulating factor. To reveal potential strain effects, we compared the operant behavior of male and female Sprague-Dawley and Wistar OBX and SHAM rats trained to self-administer palatable food pellets.
View Article and Find Full Text PDFFrom Nose to Lumbar Spinal Cord - Reduced Sperm Numbers Occur by Olfactory Bulbectomy-Related Onuf's Nucleus Degeneration: New Experimental Evidence for Kallmann Syndrome.
Neuroendocrinology
October 2023
Department of Neurology, Recep Tayyip Erdogan University, Rize, Turkey.
Introduction: Olfaction and its relation to human health is an area of growing interest. Although olfaction disorders have been considered a part of Kallmann syndrome, the role of olfactory dysfunction on spermatogenesis has not been studied yet. We studied if olfactory bulbectomy (OBX) causes dysfunction in spermatogenesis as a result of Onuf's nucleus damage.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!