AI Article Synopsis
- The study aimed to explore how the mRNA expression of PD-ECGF relates to the invasion of bladder transitional cell carcinoma (BTCC).
- The mRNA levels of PD-ECGF were found to be significantly higher in BTCC compared to normal bladder tissue, with higher levels observed in more invasive stages and grades of tumors.
- The findings indicate that PD-ECGF expression could serve as a potential marker for assessing tumor progression and guiding treatment options in BTCC.
Article Abstract
Objective: To investigate the relationship between mRNA expression of platelet-derived endothelial cell growth factor (PD-ECGF) and invasion of bladder transitional cell carcinoma (BTCC).
Methods: The mRNA expression of PD-ECGF in BTCC was detected by RT-PCR. The target PCR bands were analyzed by NIH Image 1.62 software.
Results: The mRNA level of PD-ECGF in BTCC was 3.86 times as high as that of normal bladder mucosa (t = 2.36, P < 0.05). The expression level of stage Ta, T1 and T2-4 tumor was 1.33, 4.02 and 7.59 times as high as that of normal bladder mucosa, respectively. That of Grade 3 tumor was 2.27 times as high as that of Grade 1 - 2 tumor (t = 3.52, P < 0.01).
Conclusion: The mRNA expression of PD-ECGF was positively correlated with the invasiveness and grade of BTCC. The results suggest that the mRNA level of PD-ECGF might be used as an indicator of tumor progression and a guide for clinical treatment of bladder transitional cell carcinoma.
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