In five experiments, we examined lexical competition effects using the phonological priming paradigm in a shadowing task. Experiments 1A and 1B replicate and extend Slowiaczek and Hamburger's (1992) observation that inhibitory effects occur when the prime and the target share the first three phonemes (e.g., /bRiz/-/bRik/) but not when they share the first two phonemes (e.g., /bRepsilonz/-/bRik/). This observation suggests that lexical competition depends on the length of the phonological match between the prime and the target. However, Experiment 2 revealed that an overlap of two phonemes is sufficient to cause an inhibitory effect provided that the primes mismatched the targets only on the last phoneme (e.g., /b[symbol: see text]l/-/b[symbol: see text]t/). Conversely, with a three-phoneme overlap, no inhibition was observed in Experiment 3 when the primes mismatched the targets on the last two phonemes (e.g., /bagepsilont/-/baga3/). In Experiment 4, an inhibitory effect was again observed when the primes mismatched the targets on the last phoneme but not when they mismatched the targets on the last two phonemes when the time between the offset of overlapping segments in the primes and the onset of overlapping segments in the targets was controlled for. The data thus indicate that what essentially determines prime-target competition effects in word-form priming is the number of mismatching phonemes.
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Front Immunol
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Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Donor-specific antibodies (DSAs) targeting mismatched human leukocyte antigen (HLA) molecules are one of the principal threats to long-term graft survival in solid organ transplantation. However, many patients with long-term circulating DSAs do not manifest rejection responses, suggesting a degree of heterogeneity in their pathogenicity and related functional activity. Immunologic risk stratification of transplant recipients is complicated by challenges intrinsic to defining alloantibody responses that are potentially pathogenic versus those that are not.
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Internal medicine, Shijiazhuang Fourth Hospital (Obstetrics and Gynecology Hospital Affiliated to Hebei Medical University), Shijiazhuang City, Hebei Province, 050033, China. Electronic address:
Simple yet specific miRNA detection remains an enormous challenge due to its low abundance in samples and the high similarity among homologous miRNAs. Here, we propose a novel fluorescent approach for miRNA detection with greatly elevated accuracy by utilizing exonuclease-iii (Exo-iii) assisted twice target recognition. The proposed method involves a "Sensing probe" engineered with two loop sections to facilitate dual target miRNA recognition.
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National Oceanographic and Atmospheric Administration, National Marine Fisheries Service Alaska Fisheries Science Center, Auke Bay Laboratories Juneau Alaska USA.
High-latitude ocean basins are the most productive on earth, supporting high diversity and biomass of economically and socially important species. A long tradition of responsible fisheries management has sustained these species for generations, but modern threats from climate change, habitat loss, and new fishing technologies threaten their ecosystems and the human communities that depend on them. Among these species, Alaska's most charismatic megafaunal invertebrate, the red king crab, faces all three of these threats and has declined substantially in many parts of its distribution.
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Medical Oncology Unit, Policlinico, University of Palermo, Palermo, Italy.
Patients affected by metastatic carcinoma of the colon/rectum (mCRC) harboring mutations in the BRAF gene (MBRAF) respond poorly to conventional therapy and have a prognosis worse than that of patients without mutations. Despite the promising outcomes of targeted therapy utilizing multi-targeted inhibition of the mitogen-activated protein kinase (MAPK) signaling system, the therapeutic efficacy, especially for the microsatellite stable/DNA proficient mismatch repair (MSS/PMMR) subtype, remains inadequate. Patients with MBRAF/mCRC and high microsatellite instability or DNA deficient mismatch repair (MSI-H/DMMR) exhibit a substantial tumor mutation burden, suggesting a high probability of response to immunotherapy.
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Department of Medical Oncology, Sun Yat-sen University Cancer Center, The State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University, Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, Guangdong, P. R. China.
The 2024 updates of the Chinese Society of Clinical Oncology (CSCO) Clinical Guidelines for the diagnosis and treatment of colorectal cancer emphasize standardizing cancer treatment in China, highlighting the latest advancements in evidence-based medicine, healthcare resource access, and precision medicine in oncology. These updates address disparities in epidemiological trends, clinicopathological characteristics, tumor biology, treatment approaches, and drug selection for colorectal cancer patients across diverse regions and backgrounds. Key revisions include adjustments to evidence levels for intensive treatment strategies, updates to regimens for deficient mismatch repair (dMMR)/ microsatellite instability-high (MSI-H) patients, proficient mismatch repair (pMMR)/ microsatellite stability (MSS) patients who have failed standard therapies, and rectal cancer patients with low recurrence risk.
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