This paper presents involvement of autoimmune mechanism, and especially the role of autoantibodies anti-dsDNA (double stranded DNA) in atherosclerosis. Authors on the basis of results from experimental models and human studies demonstrate contribution of antibodies anti-DNA in the pathogenesis of atherosclerosis. Antibodies anti-dsDNA may play a role in atherosclerosis by promoting accumulation of cholesterol in macrophages and smooth muscle cells, influence on dyslipoproteinemias, cytotoxicity and releasing cytocines.
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