National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, 38677, USA.
Published: April 2004
AI Article Synopsis
Article Abstract
This study examined the intestinal transport of five harman alkaloids using the Caco-2 cell monolayer as a model of the human intestinal mucosa. Transport parameters, permeability coefficients and percent transports, were calculated and compared under identical conditions with atenolol. Permeability coefficients were also compared with the reported values for model compounds like mannitol, propranolol and glucose. Sodium fluorescein was used as the marker for paracellular leakage. These alkaloids, in the concentration range of 250-500 microM, demonstrated substantial transport across the monolayer with moderate to high efflux rates and permeability coefficients. The transport was linear with time and was concentration dependent.
The study aimed to improve the barrier characteristics of polyvinyl alcohol (PVA) film by adding beeswax (BW) and glycerin and by heat treatment in order to become a potential suitable material for bread packaging. XRD, FTIR and XPS showed new cross-links between PVA and beeswax demonstrating the composite nature of the film. TGA-DTA showed that glycerin reduced the dehydration and that the beeswax improved theirs thermal stability.
In this study, the gamma radiation shielding properties of concrete samples reinforced with 10%, 20%, 30%, 40% and 50% of the cement weight of brass alloy were investigated. To test gamma shielding performance of the samples, mass and linear attenuation coefficients, half and tenth value layers, effective atomic number and radiation protection efficiency parameters were determined experimentally, theoretically and Monte Carlo simulations (GEANT4 and FLUKA). The studies were performed at 11 different gamma energies that range from 59.
To date, only four studies directly measured dermal absorption kinetics of perfluorooctanoic acid (PFOA) in human skin. Reported kinetic parameters spanned two to five orders of magnitude, demonstrating the need to determine the causes of variability and identify the most appropriate dermal absorption factors for use in exposure assessments. We evaluated the reliability and physiological relevance of studies that measured PFOA fractional absorption, steady-state flux (J), and dermal permeability coefficient (K).
Integrated Bioscience Section, Graduate School of Science and Technology, Shizuoka University, Shizuoka, 422-8529, Japan; Nanomaterials Research Division, Research Institute of Electronics, Shizuoka University, Shizuoka, 422-8529, Japan; Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka, 422-8529, Japan. Electronic address:
Most antimicrobial peptides (AMPs) induce membrane damage such as pore formation in bacterial cells, resulting in rapid cell death. On the other hand, bacterial cells have a large intracellular turgor pressure, i.e.
In order to improve the oxygen barrier performance of poly(lactic acid) (PLA), a simple and economical melt blending method was chosen and poly(vinyl alcohol) (PVOH) with excellent oxygen barrier was used as the reinforcing phase to meet high oxygen needs. To improve compatibility, PLA was grafted onto PVOH through L-LA ring opening polymerization to get poly(vinyl alcohol)-graft-poly(lactic acid) (PVOH-g-PLA). The films with high oxygen barrier performance were prepared by blending PLA with PVOH-g-PLA.
