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Quantification of intraepithelial canine melanocytes in different somatic areas.
Vet Dermatol
January 2025
Department of Veterinary Medicine, University of Perugia, Perugia, Italy.
Background: In humans, the presence of an even distribution of melanocytes within the epidermal basal layer allows for uniform pigmentation in healthy and young individuals. Moreover, despite high variability in skin colours and tones, interindividual melanocyte density variability is low. However, dogs display a high intraindividual pigmentary variability in different anatomical areas.
View Article and Find Full Text PDFDescriptive study of sweat dermatitis: A rare dermatoses not so rare in tropics.
Med J Armed Forces India
December 2024
Col AFMS (MR), O/o DGAFMS, A Block, Africa Avenue, New Delhi, India.
Background: Sweat dermatitis is an irritant inflammatory dermatosis commonly encountered in tropics during summers. Profuse sweating triggered by high heat index, friction, clothing, outdoor activities, military training, overcrowding, prolonged working in ill-ventilated places, etc., are responsible or this dermatitis.
View Article and Find Full Text PDFArticle Synopsis
- * The disease is complex and involves immune responses where CD8+ T-cells target melanocytes, and various treatment strategies include phototherapy, grafting, and new drugs like JAK-STAT inhibitors.
- * Future research should focus on exploring alternative drug targets, genetic factors, and immune cell treatments, potentially leading to more effective and lasting solutions for vitiligo.
Melanocortin 1 receptor mediates melanin production by interacting with the BBSome in primary cilia.
PLoS Biol
December 2024
Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China.
Production of melanin pigments is a protective mechanism of the skin against ultraviolet (UV)-induced damage and carcinogenesis. However, the molecular basis for melanogenesis is still poorly understood. Herein, we demonstrate a critical interplay between the primary cilium and the melanocortin 1 receptor (MC1R) signaling.
View Article and Find Full Text PDFCGG Repeat Expansion in Causing Overlapping Oculopharyngodistal Myopathy and Neuronal Intranuclear Inclusion Disease With Diffusion Weighted Imaging Abnormality in the Cerebellum.
J Clin Neurol
November 2024
Department of Neurology, The First Hospital of Shanxi Medical University, Taiyuan, China.
Background And Purpose: CGG repeat expansion in the 5' untranslated region (5'UTR) of the Notch 2 N-terminal-like C gene () has been associated with neuronal intranuclear inclusion disease (NIID) and oculopharyngodistal myopathy type 3 (OPDM3). Few OPDM3 patients have been reported. This report describes two OPDM3 patients with novel imaging findings who presented the typical features of NIID, and reviews all OPDM3 cases available in the literature.
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