AI Article Synopsis
- A study was conducted on 45 New Zealand rabbits to evaluate the effects of injecting different types of particulate plastics (PTFE and PDMS) into paralyzed vocal folds.
- The research compared a control group with a surgical nerve section to groups that received either PTFE or PDMS injections, assessing results after 6 weeks and 6 months.
- The findings showed that while both materials triggered foreign body reactions, PDMS led to increased thickness and stability of the vocal folds compared to PTFE, though significant differences in thickness were only noted in certain sections at 6 weeks.
Article Abstract
To study the augmentation of the paralyzed vocal fold in response to the injection of particulate plastics in a rabbit model, we performed a prospective, experimental, and controlled study in 45 New Zealand rabbits with surgical vocal fold paralysis. We compared a control group (acute unilateral recurrent nerve section) with a group that underwent polytetrafluoroethylene (PTFE) injection and with another group that underwent polydimethylsiloxane (PDMS) injection. Equal volumes of implant material were injected. The animals were killed either 6 weeks or 6 months after intervention and compared by histomorphology using a digital measuring system. The injection sites showed a substantial foreign body giant cell reaction against the PDMS and PTFE, surrounded by a light, fibrous stroma. No differences in the frequency of displacement or disaggregation of implants were observed. No extrusion to the laryngeal lumen, signs of migration outside the larynx, or malignant changes were seen. No differences were found in the length of the vocal fold between the PDMS group and the PTFE group. The vocal fold was thicker in the PDMS group than in the PTFE group, but a statistically significant difference was found only for the anterior and middle thirds at 6 weeks. In the PDMS sample, the thicknesses were similar in the 6-week and 6-month subgroups. The group with injection of PDMS yielded histologic images compatible with greater and more stable medialization than did the group with injection of PTFE.
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| http://dx.doi.org/10.1177/000348940411300313 | DOI Listing |
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