AI Article Synopsis
- Transplanting bone marrow mesenchymal stem cells and other cell types can help regenerate tissues, but these cells often struggle to stick to certain scaffold materials and may get damaged during the process.
- Researchers discovered that using specific lectins, like phaseolus vulgaris erythroagglutinin (PHA-E) and concanavalin A (ConA), improved the adhesion of these cells to different materials, including plastic and various biologically compatible scaffolds.
- The findings suggest that lectins could be a valuable tool in enhancing tissue engineering and cell therapy by increasing cell stability and adhesion.
Article Abstract
Transplantation of bone marrow mesenchymal stem cells (MSC), chondrocytes, osteoblasts, or muscle cells promotes regeneration. However, these cells adhere poorly to some scaffolds--depending upon the scaffold material--and are often damaged by proteases or mechanical stimuli at site of transplantation. We found, however, that MSC, chondrocytes, and osteoblasts--along with some other cells--that were exposed to phaseolus vulgaris erythroagglutinin (PHA-E) or concanavalin A (ConA) increased their adhesion capacity on plastic tissue culture dishes and on plates of hydroxyapatite, titanium and poly-DL-lactic-co-glycolic acid (PLGA), and that these cells, moreover, built up resistance to proteases and/or mechanical stimuli. Thus, lectins may have great potential in tissue engineering and cell therapy.
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| http://dx.doi.org/10.1016/j.yexcr.2003.12.018 | DOI Listing |
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