The effects of propyl paraben, an antimicrobial preservative, on voltage-dependent sodium current and myocardial ischemia-reperfusion injury were investigated in isolated adult rat cardiomyocytes. Whole cell voltage-clamp recording showed that propyl paraben reversibly blocked the voltage-gated sodium channel both in concentration- and voltage-dependent manners. Propyl paraben (500 microM but not 100 microM) significantly shifted the steady-state inactivation of the sodium channel toward the hyperpolarizing direction at the V(1/2) point. Consistent with the above result, the propidium iodide (PI) uptake test revealed that pretreatment with 500 microM but not 100 microM of propyl paraben significantly reduced cell death induced by 45 min of sustained ischemia followed by 15 h of reperfusion (42.37 +/- 7.01% of cell viability in control and 71.05 +/- 7.06% in the propyl paraben group), suggesting that propyl paraben can protect myocytes from ischemia-reperfusion injury. These results indicate a possible correlation between the inhibition of sodium current and cardioprotection against ischemia-reperfusion injury.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.lfs.2003.11.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Inactivation activity and mechanism of high-voltage pulsed electric fields combined with antibacterial agents against Alicyclobacillus spp. in apple juice.
Int J Food Microbiol
January 2025
College of Food Science and Engineering, Northwest University, Xi'an, Shaanxi 710069, China. Electronic address:
Alicyclobacillus spp. are crucial factors affecting the quality of fruit juice, so it is very important to control their contamination. In this study, the inactivation activity and mechanism of high-voltage pulsed electric fields (HVPEF) combined with antibacterial agents against Alicyclobacillus spp.
View Article and Find Full Text PDFEstablishment and validation of HPLC methods for the determination of folic acid and parabens antimicrobial agents on folic acid oral solution.
BMC Chem
January 2025
College of Food Science and Technology, Hebei Agricultural University, Baoding, 071001, China.
Background: As the common antibacterial drugs in folic acid oral liquid, parabens are listed as mandatory substances in the quality standard. Both the Chinese Pharmacopoeia and the United States Pharmacopoeia use high performance liquid chromatography for the determination of folic acid, but the quantitative methods of parabens are different. Pharmacopoeias use different instruments to quantify folic acid and parabens, resulting in cumbersome and cumbersome detection methods.
View Article and Find Full Text PDFPlastic harmful ingredients reduce the level of neurofilament light chain protein.
Ecotoxicol Environ Saf
January 2025
Orthopaedics Department of Traditional Chinese Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui 750004, China; Key Laboratory of Ningxia Ethnomedicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, Ningxia Hui 750004, China. Electronic address:
Population exposure to plastics is increasing, and plasticizers are frequently detected in humans as important ingredients of plastic products. However, patterns of exposure to harmful ingredients of plastics and their effects on neurofilament light chain (NFL), a marker of active brain pathology, are currently inconclusive. Herein, we employed a range of statistical methods to thoroughly investigate the impact of 24 plastic hazardous ingredients and their varying exposure patterns on NFL concentrations in the blood of the general population in 533 participants.
View Article and Find Full Text PDFPropyl paraben removal using CuO/ZnO-NPs photocatalyst elaborated via green method.
Environ Sci Pollut Res Int
January 2025
CPRAC Research Center, Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques, Bou-Ismail CP, Tipaza, 42004, Algeria.
The aim of the present work is to investigate the photocatalytic degradation of propyl paraben (propyl para-hydroxybenzoate, PrP) using CuO-ZnO-NPs photocatalyst followed by the identification of the oxidation by-products. The CuO-ZnO-NPs material, synthesized using a green chemistry approach, was used as a photocatalyst for the removal of PrP. The nanoparticles were characterized by XRD, XRF, diffuse reflectance spectroscopy, ATG/DTG, FTIR, SEM-EDX, BET and FRX techniques.
View Article and Find Full Text PDFUrinary concentrations of eighteen environmental phenols and the associations with feeding pattern in infants in the first 6 months of life.
Chemosphere
February 2025
Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Environmental phenols are a group of typical endocrine disruptors, and widely detectable in human breast milk and infant formulas. However, exposures data are scarce in early infancy, a particularly sensitive period to environmental pollutants exposures. We aimed to prospectively assess urinary concentrations of eighteen environmental phenols in infants from birth to 6 months of age and their associations with feeding patterns (breastfeeding, formula and mixed-feeding).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!