Chronic obstructive pulmonary disease (COPD) is characterized by increased numbers of neutrophils in the airway lumen and increased infiltration of CD8 positive T lymphocytes both in the airways and in the lung parenchyma. However, the underlying reasons for these changes have not been fully investigated. Differences in bronchoepithelial activation in COPD patients may contribute to COPD pathophysiology since the bronchial epithelium does not act as a passive barrier but has the potential to orchestrate local inflammatory reactions by releasing a variety of inflammatory mediators. The expressions of several CXC and CC chemokines were studied in primary bronchial epithelial cells derived from COPD patients and smokers without airflow limitation. In addition, cDNA array technology was used to investigate the differential bronchoepithelial expression of cytokine and cytokine-related genes in COPD patients and lifelong non-smokers without airflow obstruction. Bronchial epithelial cells from COPD patients are characterized by increased expressions of CXC chemokines but not CC chemokines. In addition, CD 146 was identified as a new adhesion molecule showing significant upregulation in primary bronchial epithelial cells derived from COPD patients, on both the steady-state mRNA and protein level. These results suggest that the bronchial epithelium plays an important role in COPD pathophysiology.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The relationship between fatigue levels and psychosocial adjustment in elderly individuals with chronic obstructive pulmonary disease: A descriptive study.
Ir J Med Sci
January 2025
Nursing Department, School of Susehri Health High, Cumhuriyet University, Sivas, Turkey.
Background: Chronic Obstructive Pulmonary Disease (COPD) is associated with physical limitations and significant social, psychological, and behavioral challenges. This study investigates the relationship between fatigue levels and psychosocial adjustment in COPD patients, considering their sociodemographic characteristics.
Methods: A descriptive study was conducted with 160 COPD patients hospitalized in the Pulmonology Department of a university hospital.
Background: Chronic obstructive pulmonary disease (COPD) patients commonly exhibit significant morbidity and experience a diminished quality of life. Since there has been no prior research on pneumonia in our study population, we carried out this study to learn more about the situation.
Methods: A retrospective analysis of 912 COPD patients with CAP who were receiving ICS treatment at the DHQ Hospital in Muzaffargarh, Punjab, Pakistan was conducted.
Optimal vocal therapy for respiratory muscle activation in patients with COPD: effects of loudness, pitch, and vowels.
Front Physiol
January 2025
Department of Rehabilitation Medicine, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, China.
Background: Vocal therapy, such as singing training, is an increasingly popular pulmonary rehabilitation program that has improved respiratory muscle status in patients with chronic obstructive pulmonary disease (COPD). However, variations in singing treatment protocols have led to inconsistent clinical outcomes.
Objective: This study aims to explore the content of vocalization training for patients with COPD by observing differences in respiratory muscle activation across different vocalization tasks.
Validation of new predictors of mortality and BODE index variants in patients with COPD at moderate altitude.
ERJ Open Res
January 2025
Department of Smoking and COPD Research, National Institute of Respiratory Diseases, Mexico City, Mexico.
Background: COPD ranks as the third leading global cause of mortality. Despite the widespread use of the BODE index and its variants for mortality prediction, their accuracy may be affected by factors like ethnicity, altitude and regional disparities. This study aimed to assess a new altitude-adapted prognostic index in COPD patients at moderate altitudes compared with the BODE and other mortality predictors.
View Article and Find Full Text PDFSymptom Network and Subgroup Analysis in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study.
Int J Chron Obstruct Pulmon Dis
January 2025
Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China.
Purpose: This study aims to construct a contemporaneous symptom network of inpatients with Exacerbation of Chronic Obstructive Pulmonary Disease (ECOPD) based on the symptom cluster, identify core and bridge symptoms, and patient subgroups with different symptom clusters based on individual differences in the intensity of patient symptom experiences.
Patients And Methods: This study used convenience sampling to collect demographic, symptom, auxiliary examination, and prognosis information of 208 inpatients with ECOPD from April 2022 to October 2023. The data underwent exploratory factor analysis (EFA), symptom network analysis, latent class analysis (LCA), Spearman correlation analysis, Wilcoxon signed-rank test, single-factor regression and multiple-factor stepwise regression.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!