Neuroendocrine tumors are an interesting group of neoplasmas of the digestive system. A possibility of appearance of syndromes connected with hormonal activity is their common feature. Some of them are not hormonally active and they do not manifest hormonal hyperactivity. The authors present 2 patients with malignant neuroendocrine pancreatic tumors in whom the lack of clinical syndromes connected with overproduction of hormone resulted in the establishment of the diagnosis in an advanced stage of the disease. The tumors were not clinically active but immunohistochemical examinations revealed the presence of hormones in cytoplasmatic granules. Both patients had positive immunostaining for VIP, NSE and chromogranin. Moreover, in one of the patients positive staining for ACTH and glucagon and in another for PGP 9.5 was obtained.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Altered Neural Activity in the Mesoaccumbens Pathway Underlies Impaired Social Reward Processing in Shank3-Deficient Rats.
Adv Sci (Weinh)
March 2025
Department of Psychiatry, New York, NY, USA.
Social behaviors are crucial for human connection and belonging, often impacted by conditions like Autism Spectrum Disorder (ASD). The mesoaccumbens pathway (ventral tegmental area (VTA) to the nucleus accumbense (NAc)) plays a pivotal role in social behavior and is implicated in ASD. However, the impact of ASD-related mutations on social reward processing remains insufficiently explored.
View Article and Find Full Text PDFUnraveling Hematological Anomalies in DiGeorge Syndrome: A Retrospective Study of Thrombocytopenia and Mean Platelet Volume.
Cureus
February 2025
Pediatrics, Alexandria University, Alexandria, EGY.
Background: DiGeorge syndrome, arising from chromosome 22q11.2 deletion including the gene, is known for its multifaceted developmental anomalies affecting the heart, immune system, and facial morphology. Despite extensive clinical characterization, hematological manifestations, particularly thrombocytopenia, remain underexplored.
View Article and Find Full Text PDFPrenatal Alcohol Exposure Inhibits Transient Expression of Autophagy and Synaptic Proteins in Developing Brain.
Obstet Gynecol Res
January 2025
Center for Neural Development and Repair, Department of Neural Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Introduction: Neuronal apoptosis and consequent inhibition of autophagy, with loss of synaptic connections are central events in the genesis of fetal alcohol spectrum disorders (FASD). However, studies of molecular mechanisms of autophagy in human fetal brain are limited. Recently, prenatal exposure to EtOH was associated with reduced miRNA-9 levels in fetal brain-derived exosomes (FB- Es) isolated from maternal plasma, which correlated with small eyes, an anatomical hallmark of fetal alcohol syndrome (FAS).
View Article and Find Full Text PDFmiR-34a-5p modulation of polycystic ovary syndrome via targeting the NOTCH signaling pathway.
J Ovarian Res
March 2025
Department of Obstetrics, The Affiliated Hospital of Qingdao University, 59 Haier Road, Qingdao, 266000, China.
Purpose: Polycystic ovary syndrome (PCOS) is currently recognized as a condition that affects several systems in the body, including the reproductive, endocrine, and cardiovascular systems. Prevalent among teenagers and women of reproductive age. Prior research has demonstrated an elevation of miR-34a-5p within the follicular fluid (FF) of women of PCOS.
View Article and Find Full Text PDFPromising protective treatment potential of endophytic bacterium for ulcerative colitis in rats.
J Zhejiang Univ Sci B
January 2025
Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt.
Ulcerative colitis (UC) is an inflammatory condition of the intestine, resulting from an increase in oxidative stress and pro-inflammatory mediators. In this study, the extract of endophytic bacterium was prepared for the first time using liquid chromatography-mass spectrometry (LC-MS). In addition, also for the first time, the protective potential of was revealed using an in vivo rat model of UC.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!