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Neuroinflammation in neocortical epilepsy measured by PET imaging of translocator protein.
Epilepsia
June 2019
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Objectives: Neuroinflammation, implicated in epilepsy, can be imaged in humans with positron emission tomography (PET) ligands for translocator protein 18 kDa (TSPO). Previous studies in patients with temporal lobe epilepsy and mesial temporal sclerosis found increased [11C]PBR28 uptake ipsilateral to seizure foci. Neocortical foci present more difficult localization problems and more variable underlying pathology.
View Article and Find Full Text PDFTemporal lobe epilepsy surgery failures: a review.
Epilepsy Res Treat
August 2012
Division of Neurology, Hôpital Notre-Dame du CHUM, University of Montreal, Montreal, QC, Canada H2L 4M1.
Patients with temporal lobe epilepsy (TLE) are refractory to antiepileptic drugs in about 30% of cases. Surgical treatment has been shown to be beneficial for the selected patients but fails to provide a seizure-free outcome in 20-30% of TLE patients. Several reasons have been identified to explain these surgical failures.
View Article and Find Full Text PDFMicroencephaloceles: another dual pathology of intractable temporal lobe epilepsy in childhood.
J Neurosurg Pediatr
April 2010
Department of Neurosurgery, Frenchay Hospital, Bristol, United Kingdom.
Temporal lobe encephaloceles can be associated with temporal lobe epilepsy. The authors report on the case of an adolescent with multiple microencephaloceles, in the anterolateral middle fossa floor, identified at surgery (temporal lobectomy) for intractable partial-onset seizures of temporal origin. Magnetic resonance imaging revealed only hippocampal atrophy.
View Article and Find Full Text PDF[Dual pathology].
Neurochirurgie
May 2008
Service de neurochirurgie, hôpital Pellegrin-Tripode, CHU de Bordeaux, 1, place Amélie-Raba-Léon, 33000 Bordeaux, France.
Dual pathology is defined as the association of two potentially epileptogenic lesions, hippocampal (sclerosis, neuronal loss) and extrahippocampal (temporal or extratemporal). Epileptic activity may be generated by either lesion and the relative importance of every lesion's epileptogenicity conditions the surgical strategy adopted. Most frequently associated with hippocampal sclerosis are cortical dysplasias.
View Article and Find Full Text PDFLandau-Kleffner syndrome with lateral temporal focal cortical dysplasia and mesial temporal sclerosis: a 30-year follow-up.
Epilepsy Behav
May 2007
Department of Neurology, Comprehensive Epilepsy Program, Rhode Island Hospital, 110 Lockwood Street, Suite 342, Providence, RI 02903, USA.
A 39-year-old man, who presented at age 312 with Landau-Kleffner syndrome, had persisting oral and written language deficits into adulthood. Seizures were easily controlled in childhood, but reemerged in adulthood as medication-refractory complex partial seizures. Abnormal T2 signal hyperintensity was seen in the left mesial temporal area on brain MRI.
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