OBJECTIVE:The aim of this study was to investigate the expression of the adhesion molecules in human salivary adenoid cystic carcinoma(ACC) cell lines (ACC-2 line and ACC-M strain) which had different metastatic ability.METHODS:The expression of adhesion molecules,which included CD44s,CD44v6,E cadherin,alph-catenin and beta-catenin in two human salivary ACC cell lines and Scid mice neoplasm models was investigated by immunohistochemistry. RESULTS: (1)Positive staining of adhesion molecules in lung metastatic foci of ACC was higher than that in subcutaneous implanted tumor mass.(2)The growing of ACC-M was slower in the cells of abdominal cavity implanted tumor,and also the differentiation of the former was better than the latter.(3)Weaker Positive staining of CD44v6 in ACC cells in vitro was showed,however,no positive staining was detected in lung metastatic foci cells of ACC M and the cells of subcutaneous tumor.CONCLUSION: The expression of CD44s in ACC cells was influenced by cell differentiation,and may affect the growth conditions;The expression levels of E cad/cat was positively correlative to the differentiation of ACC tumor cells;No significant correlation was revealed between the expression of CD44v6 and metastatic ability of ACC.
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