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Treatment for essential tremor: a systematic review and Bayesian Model-based Network Meta-analysis of RCTs.
EClinicalMedicine
November 2024
Center for movement disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Background: Essential tremor (ET) significantly impacts patients' daily lives and quality of life, presenting a considerable challenge in clinical practice. In recent years, novel therapeutic regimens have been investigated in randomized controlled trials (RCTs). This study aims to investigate and evaluate the relative efficacy and safety of various therapeutic interventions for ET.
View Article and Find Full Text PDFMechanisms of tremor-modulating effects of primidone and propranolol in essential tremor.
Parkinsonism Relat Disord
November 2024
Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia; Medical Faculty, University of Ljubljana, Ljubljana, Slovenia. Electronic address:
Introduction: Primidone and propranolol are primary treatments for essential tremor, however the exact mechanisms underlying their efficacy are not fully elucidated. Understanding how these medications alleviate tremor may guide the development of additional pharmacologic treatments. Our prospective observational study employed transcranial magnetic stimulation (TMS) to explore mechanisms of primidone and propranolol effects in essential tremor.
View Article and Find Full Text PDFMicroRNA Guided In Silico Drug Repositioning for Malaria.
Acta Parasitol
December 2024
Department of Biotechnology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Background: The rise in Plasmodium resistant strains, decreasing susceptibility to first-line combination therapies, and inadequate efficacy shown by vaccines developed to date necessitate innovative approaches to combat malaria. Drug repurposing refers to finding newer indications for existing medications that provide significant advantages over de novo drug discovery, leading to rapid treatment options. Growing evidence suggests that drugs could regulate the expression of disease-associated microRNAs (miRNAs), implying the potential of miRNAs as attractive targets of therapy for several diseases.
View Article and Find Full Text PDFAlgorithm-based Management of Infantile Hemangiomas: Reducing Sequelae and Surgical Interventions.
Plast Reconstr Surg Glob Open
September 2024
From the Department of Plastic and Reconstructive Surgery, Nippon Medical School Musashi Kosugi Hospital, Kawasaki, Kanagawa, Japan.
Article Synopsis
- In Japan, there's a need for a standardized treatment algorithm for infantile hemangioma (IH) that weighs effectiveness, side effects, and aesthetic concerns, as current treatment options—oral propranolol and pulsed dye laser—have no out-of-pocket costs for patients.
- A retrospective study of 156 IH patients showed that using an aesthetic risk assessment helped guide treatment choices based on individual cases, with a high interrater reliability for the risk scoring system.
- The results indicated that patients who followed the algorithm experienced significantly fewer complications and tended to have shorter treatment times and fewer laser sessions compared to those who did not comply with the algorithm.
Dopamine and Norepinephrine Differentially Mediate the Exploration-Exploitation Tradeoff.
J Neurosci
October 2024
Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455
Article Synopsis
- Dopamine (DA) and norepinephrine (NE) play distinct but overlapping roles in decision-making processes, particularly in the exploration-exploitation tradeoff, where individuals balance trying new options versus sticking with known rewards.
- A study involving male and female mice used a two-armed bandit task to observe how various drugs affecting DA and NE influenced exploration behavior, revealing that increasing DA decreased exploration while decreasing DA had the opposite effect.
- The findings indicate that DA and NE have different mechanisms in regulating exploration, with DA affecting decision noise and NE impacting sensitivity to outcomes, highlighting the complex interplay between these neuromodulators in decision-making.
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