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Linkage of the metabolic syndrome to 1q23-q31 in Hispanic families: the Insulin Resistance Atherosclerosis Study Family Study. | LitMetric

AI Article Synopsis

  • The metabolic syndrome is defined by features such as obesity, high cholesterol, elevated blood pressure, and high blood sugar levels.
  • The IRAS Family Study investigated Hispanic families from San Antonio, TX, and San Luis Valley, CO, finding that 35% of individuals in certain families had metabolic syndrome, with significant rates of related conditions like high waist circumference and low HDL cholesterol.
  • Nonparametric linkage analysis linked the metabolic syndrome to a specific region on chromosome 1 (1q23-q31) and suggested differences in prevalence between the two study locations might be due to factors like age, obesity levels, and environment.

Article Abstract

The metabolic syndrome is characterized by central obesity, dyslipidemia, elevated blood pressure, and hyperglycemia. The Insulin Resistance Atherosclerosis Study (IRAS) Family Study recruited extended pedigrees of Hispanic descent from San Antonio, TX (SA) and San Luis Valley, CO (SLV). Thirty-five of these pedigrees (27 SA and 8 SLV) had at least 2 individuals with metabolic syndrome (216 affected individuals and 563 affected relative pairs). The prevalence of metabolic syndrome and component criteria in subjects from these pedigrees were 35% metabolic syndrome, 43% increased waist circumference, 31% hypertriglyceridemia, 69% low HDL cholesterol, 31% increased blood pressure, and 25% either increased fasting glucose or presence of diabetes. Nonparametric linkage analysis provided evidence for linkage of metabolic syndrome to 1q23-q31 (D1S518; logarithm of odds [LOD] 1.6) with significant site heterogeneity (SA LOD 2.6 and SLV LOD 0.0), and removing all individuals with diabetes reduced, but did not eliminate, the evidence for linkage to this region (LOD 1.2). This heterogeneity may partially be explained by phenotypic differences. Members in the SA pedigrees were older, had greater central obesity, had higher prevalence of the metabolic syndrome, and were from a more urban environment than members of the SLV pedigrees. These results contribute to the growing evidence that chromosome 1q harbors at least one locus related to the metabolic precursors of diabetes.

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Source
http://dx.doi.org/10.2337/diabetes.53.4.1170DOI Listing

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