First-choice antibiotics at subinhibitory concentrations induce persistence of Chlamydia pneumoniae.

Antimicrob Agents Chemother

Institute of Medical Microbiology and Hygiene, University of Lübeck, 23538 Luebeck, Germany.

Published: April 2004

Persistent growth forms of Chlamydia pneumoniae have been associated with chronic infections in vivo. We investigated the effects of first-line therapeutics on the induction of persistence by monitoring recoverable organisms, gene expression of membrane proteins, and morphology. We found that all of the antibiotics tested have distinct and subinhibitory concentrations at which they induce persistence.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC375316PMC
http://dx.doi.org/10.1128/AAC.48.4.1402-1405.2004DOI Listing

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