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Expression of heat shock proteins in human hepatocellular carcinoma after radiofrequency ablation in an animal model.
Oncol Rep
September 2004
Department of Radiology, University Hospital Vienna, Waehringer Guertel 18-20/7F, A-1090 Vienna, Austria.
Since tumor cells are known to express heat shock proteins (HSPs) as a response to cellular stress, such as heat, our goal was to determine the expression of HSPs in human hepatocellular carcinoma (HCC) before and after percutaneous radiofrequency (RF) ablation using a rat model. In 12 nude rats, human HCC cells (SK-HEP-1) were inoculated subcutaneously. A total of 21 tumors were grown in the bilateral flanks of the rats.
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