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Integr Environ Assess Manag
January 2025
International Institute for Sustainable Development-Experimental Lakes Area, Winnipeg, Manitoba, Canada.
Selenium (Se) is a naturally occurring metalloid in soils and rocks that is released by weathering processes; it is also enriched by some anthropogenic activities, including mining and agriculture. The mechanism of Se aquatic toxicity has been understood for several decades; at elevated concentrations, dietary Se can accumulate in maternal tissues of fish and birds, become deposited into their eggs, and can potentially result in impaired embryological development. North American environmental regulations have acknowledged differences in species sensitivity and variation among aquatic environments (i.
View Article and Find Full Text PDFIntroduction Acute poisoning in children is still a global health concern that necessitates visiting the emergency department that might associated with morbidity and mortality. It has an impact on social, economic, and health issues, particularly for children under five who account for the majority of poisonings worldwide. Poisoning can result in mild cases, serious complications, or even death; oral ingestion is the most common way that poisoning occurs in children.
View Article and Find Full Text PDFIntegr Environ Assess Manag
January 2025
Formation Environmental, Boulder, CO, USA.
Offspring of adult Yellowstone cutthroat trout (YCT) exposed to a range of selenium (Se) concentrations in situ were reared in a laboratory setting to assess effects on survival, growth and abnormalities. Maternal whole body Se concentrations ranged from 2.6 to 25.
View Article and Find Full Text PDFBirth Defects Res
February 2025
Translational Research Division, Chugai Pharmaceutical Co. Ltd., Chuo, Japan.
Background: Nemolizumab, a humanized monoclonal antibody against interleukin-31 receptor A (IL-31RA), is used to treat atopic dermatitis and prurigo nodularis. These inflammatory skin diseases affect a wide range of age groups, including pregnant women and children; however, little is known about their biological effects on pre- and postnatal development. Therefore, we report and discuss the results of an enhanced pre- and postnatal development study in cynomolgus monkeys treated with nemolizumab, which also incorporates an assessment of juvenile toxicities.
View Article and Find Full Text PDFEndocrinol Diabetes Metab Case Rep
January 2025
Summary: Vitamin D is commonly recommended for daily intake as dietary sources are often insufficient. However, prolonged high-dose use can lead to serious complications. We present a rare case of a 2-month-old infant who developed severe hypercalcemia and hypertriglyceridemia due to an accidental overdose of 25-OH vitamin D, leading to hypertriglyceridemia and pancreatitis.
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